期刊文献+

5-甲基四氢叶酸抗氧化效应强于维生素C(英文) 被引量:7

Antioxidant Effect of 5-Methyltetrahydrofolate Stronger Than Ascorbic Acid
原文传递
导出
摘要 在公认的生化抗氧化剂中,目前还未明确地列入5-甲基四氢叶酸.根据5-甲基四氢叶酸的化学结构,它应该具有强氧化性从而能够有效地保护其它维生素的光降解.本文据此研究了5-甲基四氢叶酸的抗氧化效应.选择光敏感维生素核黄素作为光降解剂.使用荧光光谱仪记录和分析了核黄素分别在叶酸和公认的抗氧化剂维生素C作用下的光降解光谱,以此比较分析它们的抗氧化效应.结果发现,当5-甲基四氢叶酸加入时,核黄素光降解明显变慢,而维生素C的作用不如5-甲基四氢叶酸明显.数据显示,5-甲基四氢叶酸具有明显的抗氧化效应,而且其抗氧化效应较维生素C强. Implied from the chemical structure of 5-methyltetrahydrofolate,it might have a strong antioxidant activity to protect other vitamins against photodegradation.To investigated this possible antioxidant effect,photosensitizing vitamin riboflavin was selected as the degradation agent.The absorption spectra of riboflavin alone was compared with those of in the presence 5-methyltetrahydrofolate or ascorbic acid,a well known antioxidant vitamin.We found that 5-methyltetrahydrofolate decreased the degradation of riboflavin more significantly than ascorbic acid according to the analyses of absorption spectra. We concluded that 5- methyhetrahydrofolate had a stronger antioxidant effect than ascorbic acid.
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2009年第9期824-827,共4页 Chinese Journal of Biochemistry and Molecular Biology
基金 Supported by Foundation from Norwegian Radium Hospital,Norway~~
关键词 5-甲基四氢叶酸 维生素C 核黄素 抗氧化剂 5-methyltetrahydrofolate ascorbic acid riboflavin antioxidant
  • 相关文献

参考文献16

  • 1Gutteridge J M, Halliwell B. Comments on review of Free Radicals in Biology and Medicine, second edition. [ J ]. Free Radic Biol Med, 1992, 12( 1 ) : 93-95.
  • 2Knight J A. Free radicals: their history and current status in aging and disease[J]. Ann Clin Lab Sci, 1998, 28(6) :331-346.
  • 3Sies H. Oxidative stress: oxidants and antioxidants[J]. Exp Physiol, 1997,82 (2) :291-295.
  • 4Maxwell S R. Prospects for the use of antioxidant therapies [ J ]. Drugs, 1995,49(3) :345-361.
  • 5Clarkson P hi. Antioxidants and physical performance[J].Crit Rev Food Sci Nutr, 1995, 35(1-2) :131-141.
  • 6Witt E H, Reznick A Z, Viquie C A, et al. Exercise, Oxidative Damage and Effects of Antioxidant Manipulation[J]. J Nutr, 1992, 122(3 suppl) :766-773.
  • 7杨开艳,顾建兰,殷冬梅,沈勤.姜黄素对脂多糖激活的小胶质细胞iNOS表达的抑制及抗氧化作用[J].中国生物化学与分子生物学报,2007,23(11):938-945. 被引量:24
  • 8Panda A K, Ramarao S V, Raju M V, et al. Effect of dietary supplementation with vitamins E and C on production performance, immune responses and antioxidant status of White Leghorn layers under tropical summer conditions [ J ], Br Poult Sci, 2008,49 ( 5 ) : 592-599.
  • 9Rubinoff A B, Lamer PA, Pasut LA.. Vitamin C and oral health[J].J Can Dent Assoc, 1990, 55(9) :705-707.
  • 10Robertson J M, Donner A P, Trevithick J R. A possible role for vitamins C and E in cataract prevention[J]Am J Clin Nutr, 1991,53 (1 Suppl. ) : 346S-351S.

二级参考文献5

共引文献23

同被引文献50

引证文献7

二级引证文献37

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部