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雌激素对去卵巢大鼠大脑皮质和海马中Bcl-2和Bax蛋白表达的影响 被引量：5

Effects of estrogen on Bcl-2 and Bax in cerebral cortexes and hippocampus of rat
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摘要 利用免疫组织化学超敏SP法检测SD大鼠摘除卵巢及外源性17β-雌二醇治疗后大脑皮质和海马中Bcl-2和Bax蛋白表达的变化。结果显示,摘除双侧卵巢后,大鼠大脑皮质和海马中Bcl-2不同程度降低,而Bax的表达出现不同程度的上升,17β-雌二醇治疗后,2种蛋白的表达基本恢复正常。表明雌激素能够不同程度的上调大脑皮质和海马中Bcl-2蛋白的表达,下调Bax蛋白的表达,从而对大脑皮质及海马神经元具有保护作用。 The expression of Bcl-2 and Bax in the cerebral cortexes and hippocampus of rat after ovariectormized and treated with 17β- estrogen were detected by the method of Streptavidin-Perosidase （SP） immunohistochemistry. Results show that 17β-estradiol can prevent the neuron of cerebral cortexes and hippocampus from apoptosis by upregulating the expression of Bcl-2 and down-regulating Bax in different levels.
作者 阿依木古丽 蔡勇 范光丽
机构地区 西北民族大学生命科学与工程学院 西北农林科技大学动物医学院 西北民族大学实验中心
出处 《中国兽医学报》 CAS CSCD 北大核心 2009年第10期1307-1309,1314,共4页 Chinese Journal of Veterinary Science
基金 西北民族大学中青年基金资助项目([2007]13) 西北民族大学中青年基金资助项目([2006]24)
关键词 雌激素 BCL-2 BAX 大脑皮质 海马 estrogen Bcl-2 Bax cerebral cortexes hippocampus
分类号 S814.1 [农业科学—畜牧学]
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参考文献23

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二级参考文献59

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中国兽医学报
2009年 第10期

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