摘要
TTX是一种氨基全氢化喹唑啉化合物,是豚毒鱼类及其他生物体内含有的一种生物碱,也是一种强烈的神经毒素,较低的浓度就能选择性地抑制钠离子通过神经细胞膜。本文简要介绍TTX的化学特性及其微生物来源,由于目前国内外尚无微生物来源的TTX合成方面的详细报道,而与TTX有类似结构和类似性质的石房蛤毒素和膝沟藻毒素的微生物合成均与精氨酸和乙酸的代谢有关,这些为TTX的微生物合成提供了参考。综述微生物降解TTX的类似结构化合物的研究成果,以此为基础探讨微生物转化降解TTX使之由剧毒变为毒性减弱乃至无毒的可能性,并展望微生物转化降解TTX的发展趋势。
Tetrodotoxin （TTX） is a kind of amino-perhydrogenated quinazoline compound, which is an alkaloid in dolphin and other organisms. TTX is a strong neurotoxin and can selectively inhibit sodium ion transportation across nerve cell membrane at a low concentration. In this paper, chemical properties and microbial resource of TTX are reviewed. Currently, detailed investigations related to microbial synthesis of TTX have been less reported. However, microorganism synthesis of highly toxic substances such as saxitoxin and gonyautoxin with similar structures and properties as TTX has been reported to implement through arginine and acetate metabolisms. These previous investigations will also provide references for microorganism synthesis of TI＇X. Similarly, summarizing these achievements relative to microorganism degradation, a possibility or developing trend to degrade tetrodotoxin from high toxicity to low or no toxicity through microorganism transformation is proposed.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2009年第19期341-345,共5页
Food Science
基金
上海市科委部分地方院校计划项目(08390513900)
"十一五"国家科技支撑计划项目(2008BAD94B09)
关键词
微生物合成
TTX
转化
降解
microbial synthesis
tetrodotoxin
transformation
degradation
