摘要
目的探讨复治肺结核患者对常用抗结核药物的耐药特点。方法对285例复治肺结核病例进行抗结核药物敏感性测定。结果对异烟肼(INH)耐药118例(41.4%),对利福平(RFP)耐药71例(24.9%),对链霉素(SM)耐药134例(47.0%),对吡嗪酰胺(PZA)耐药62例(21.8%),对乙胺丁醇(EMB)耐药87例(30.5%)。耐1种药57例(20.0%),耐2种药91例(31.9%),耐3种药81例(28.4%),耐4种药31例(10.9%),耐5种药25例(8.8%)。同时耐2～3种药物的病例明显多于耐4～5种药物者(60.3%vs.19.7%)(P<0.01)。结论复治肺结核病例容易对一线抗结核药物产生耐药性,通常需联合使用部分二线抗结核药物治疗。
Objective To investigate the features of drug resisthnce in the patients with retreated pulmonary tuberculosis with common antitubereulotics. Methods The sensibility of tubercule bacillus to the antituberculoties was tested in 285 patients with retreated pulmonary tuberculosis. Results Of 285 patients,118 cases（41.4%） had a drug resistance to isoniazid,71 cases （24.9%） had a drug resistance to rifampicinthe, 134 cases （47.0%） had a drug resistance tO streptomycin, 62 cases （21.8%） had a drug resistance to pyrazinamide, 87 cases （30.5%） had a drug resistance to ethambutol. The percentage of having drug resistance to 2 to 3 first-line antituberculotics was more than that to 4 to 5 drugs resistance （60. 3% vs. 19.7%）（P〈0. 01）. Conclusion The patients with retreated pulmonary tuberculosis are easy to produce drug resistance to the first-line antituberculotics and commonly need a combined Use of the second-line antituberculotics.
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第10期1165-1166,共2页
Jiangsu Medical Journal
关键词
复治肺结核
抗结核药
药物敏感
药物耐受
Retreated pulmonary tuberculosis
Antituberculotic
Drug susceptibility
Drug resistance
