摘要
目的:探讨采用胸腔内灌注胶体磷酸32P铬注射液(32P胶体)和顺铂治疗恶性肿瘤大量胸腔积液的临床疗效和副反应.方法:46例恶性胸腔积液患者随机分为两组,治疗组25例,对照组21例.在胸腔闭式引流使胸水量减少到一定程度后,治疗组分别采用32P胶体和顺铂胸腔内灌注治疗,对照组以32P胶体单纯胸腔内灌注治疗.结果:治疗组可统计病例24例,临床反应完全缓解(CR)11例(45.8%),部分缓解(PR)9例(37.5%),无效(NC)4例(16.7%),总有效率83.3%,其中5例CR和2例PR患者经2 mo的观察无明显的复发;对照组CR 1例(4.8%),PR 7例(33.3%),NC 13例(61.9%).治疗组总有效率明显高于对照组(χ2=9.75,P<0.01),副作用主要是轻度全身反应和轻度骨髓抑制.结论:中心静脉导管胸腔闭式引流后胸腔内注入32P胶体及顺铂是临床上治疗恶性胸腔积液的有效方法,无严重不良反应.
AIM： To investigate the clinical efficacy and the side effects of intrapleural injection with colloidal chromium phosphate （^32P ） plus cisplatin for treating malignant pleural effusion. METHODS： Forty-six patients with malignant pleural effusion were randomly divided into the therapeutic group （ n = 25） and the control group （n = 21 ）. Cisplatin and ^32P were injected into pleural cavity in therapeutic group, and only ^32P was given in control group. RESULTS： Twenty-four patients were evaluated in therapeutic group with clinical response, including 45.8% （11/24）, PR 37.5% （9/24）, NC 16.7% （4/24）. The totle effective rate is 83.3%. There were no recurrence of 5 CR patients and 2 PR patients after 2 months follow-up. The clinical response in control group were CR 4.8% （ 1 case） , PR 33.3% （7 cases） , NC 61.9% （13 cases）. The total effective rate in therapeutic group was higher than those in control group （ x^2 = 9.75, P 〈 0.01 ）. The main side effects among therapeutic course were mild systemic reaction and mild bone marrow suppression. CONCLUSION： Intrapleural injection with ^32P combined with cisplatin seem to be an effective method for treating malignant pleural effusion without serious complication.
出处
《第四军医大学学报》
北大核心
2009年第18期1802-1804,共3页
Journal of the Fourth Military Medical University
关键词
恶性胸腔积液
^32P胶体
顺铂
胸腔内灌注
malignant pleural effusion
colloidal chromium phos phate （ ^32P ）
cisplatin
intrapleural injection
