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抗线粒体抗体阴性原发性胆汁性肝硬化的临床及自身免疫学特征分析 被引量:2

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摘要 目的研究抗线粒体抗体(AMA)阴性原发性胆汁性肝硬化(PBC)的临床及自身免疫学特点,提高临床对PBC的诊断水平。方法选取临床及病理确诊的131例PBC患者AMA阴性为A组,AMA阳性为B组。回顾性分析发病年龄、性别、合并症、主要临床表现、免疫生化指标、抗核抗体(ANA)、抗gp210、抗spl00等。结果131例患者中,A组19例,占14.5%,A组除IgG、IgM较B组升高略低[分别为(8.6±2.7)g/L比(12.0±5.5)g/L、(4.2±0.6)g/L比(4.8±2.5)g/L,P〈0.01或〈0.05]外,其他指标差异无统计学意义。ANA检查A组以核包膜阳性和多核点阳性为主,B组以着丝点阳性为主。抗gp210、抗sp100阳性两组之间差异无统计学意义。结论血清中ANA阳性及抗gp210、抗sp100阳性有助于AMA阴性PBC的诊断。
出处 《中国医师进修杂志(内科版)》 2009年第10期52-54,共3页 Chinese Journal of Postgraduates of Medicine
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