摘要
目的探讨C反应蛋白(CRP)和体温对于恶性血液病患者感染及感染严重程度的临床诊断价值。方法对上海市第一人民医院血液科2004年5月-2005年5月收治入选的已行CRP检查的119例恶性病患者按照病原学和抗菌药物应用情况分为感染组和非感染组进行CRP浓度及体温的比较。结果感染组与非感染组CRP浓度及体位差异有统计学意义(P<0.01,P<0.05);CRP曲线下面积(AUC)为0.924,体温AUC为0.864,CRP浓度对于感染的鉴别值为54.5 mg/L,其敏感性分别为87.8%,特异性分别为75.2%,体温对于感染的鉴别值为38.3℃;其敏感性分别为83.7%,特异性分别为73.2%;CRP联合体温对于感染鉴别的敏感性和特异性分别为92.3%、75.6%。结论CRP和体温可以做为血液恶性病患者感染的良好辅助诊断指标,尤其是CRP联合体温,敏感性高。
OBJECTIVE To analyze and compare the value of c-reactive protein（CRP） and body temperature in the infection diagnosis and severity of infection among the patients with malignant hematological disease. METHODS According to the microorganism detection and application of antibiotics, we divided the 119 patients into infection group and noninfection group from May 2004 to May 2005 in our ward. CRP and temperature of the patients were measured and. RESULTS There were 88 cases in the infection group and 31 cases in the noninfection group. The CRP plasma concentration had significant difference between too groups （P〈0.01）. Also the body temperature was significantly different between them （P〈0.05）. The area under curve（AUC） of CRP was 0. 924 and its cutoff value was 54.5 mg/L. Its sensitivity and specificity were 87.8% and 75.2%, respectively. The AUC of the body temperature was 0. 863 and its cutoff value was 38. 3 ℃. Its sensitivity and specificity were 83. 7% and 73.2%. The sensitivity and specificity of combination of CRP and body temperature were 92.3% and 75.6%. CONCLUSIONS CRP and body temperature are helpful indicators of infection in the patients with malignant hematological disease. The combination of the two indicators has higher sensitivity.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第20期2697-2700,共4页
Chinese Journal of Nosocomiology
关键词
C反应蛋白
感染
恶性血液病
CRP
Infection
Malignant hematological disease
