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具有切割DNA活性的铬配合物 被引量：2

Chromium Complexes with Cleaving DNA Activity
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摘要 铬配合物切割DNA的活性在医学、药学及生物学领域引起了广泛关注。本文综述了具有切割DNA活性的铬配合物的研究进展,介绍了不同价态铬的多种配位模式配合物切割DNA的活性,总结了铬配合物切割DNA的作用机理,展望了不同价态铬配合物的研究和发展方向。 Study on cleavage DNA activity of chromium complexes attracts aboard attention owing to theirs important application prospects in medical, pharmaceutical and biology fields. In this paper, the research progress of chromium complexes with cleaving DNA activity is reviewed. The studies of the chromium complexes of various coordination mode and structure-activity relationship in this field are introduced. The action mechanism of the chromium complexes are summarized. Finally, the research and development trends of chromium complexes with different valences are put forward.
作者 岳蕾 周荫庄
机构地区 首都师范大学化学系
出处 《化学进展》 SCIE CAS CSCD 北大核心 2009年第10期2093-2099,共7页 Progress in Chemistry
基金 北京市教育委员会项目(No.KM200510028005)资助
关键词 铬配合物 切割DNA 配位模式 氧化 水解 Cr complexes cleavage DNA coordination mode oxidative hydrolytive
分类号 O614.611 [理学—无机化学]
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参考文献59

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同被引文献25

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化学进展
2009年 第10期

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