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万汶与贺斯在胃癌手术前高容量血液稀释中应用的临床观察 被引量:1

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摘要 目的观察万汶与贺斯行高容量血液稀释(acute hypervolemic hemodilution,AHH)在连续硬膜外阻滞复合全身麻醉下行胃癌根治术时的疗效观察。方法 ASAⅠ~Ⅱ级患者52例,随机分成万汶组(Ⅰ组)和贺斯组(Ⅱ组),各26例,手术前20 min开始进行血液稀释,Ⅰ组输注万汶,Ⅱ组输注贺斯,总量均为15 mL/kg,加压输入速度为30 mL/min。记录AHH前后2组患者平均动脉压(mean a rterial pressure,MAP)、中心静脉压(centralvenous pressure,CVP)、心率(heart rate,HR)、脉搏血率饱和度(SpO_2),并经桡动脉采血,测定血红蛋白(hemoglobin,Hb)、Hct、血小板(platelet,PLT)、电解质(K^+、Na^+、Ca^(2+))及血气等指标。结果术中2组患者出血量和输液量差异无统计学意义(P>0.05),AHH前后2组患者Hb,Hct,PLT均显著下降(P<0.05),其中Hb、Hct 2组间差异无统计学意义,而贺斯对PLT的影响比万汶更大(P<0.05),但均在正常范围内;MAP、HR无显著变化(P>0.05),而CVP有所升高(P<0.05),但在正常范围内;血气、血Na^+、血Ca^(2+)无明显变化(P>0.05),而血K^+下降明显(P<0.05)。结论连续硬膜外阻滞复合全身麻醉下胃癌手术患者采用万汶或贺斯施行AHH,可有效维持血流动力学平稳及提高对失血的耐受性,但应注意术前合并电解质紊乱、特别是血K+过低者,应及时纠正。
作者 傅颖 张建宇
出处 《河北医科大学学报》 CAS 2009年第6期603-605,共3页 Journal of Hebei Medical University
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