摘要
目的研究临床分离的对耐高浓度庆大霉素(HLGR)肠球菌的检测和耐药性。方法用纸片扩散法、琼脂筛选法2种方法对临床分离的140株肠球菌属进行高浓度庆大霉素耐药的检测,试验数据利用WHONET5.3软件分析处理。结果2种方法的检测结果基本一致,检出73例高耐药株,分离率为52.1%,67例非高耐药株,分离率为47.9%。高耐药性肠球菌属的耐药率远远高于非高浓度耐药性肠球菌属,检出5株耐万古霉素肠球菌,分离率为3.6%。结论肠球菌属感染以粪肠球菌、屎肠球菌为主;肠球菌属总体耐药率较高,屎肠球菌耐药性高于粪肠球菌。临床上应选用合适的方法进行高浓度耐药性肠球菌属的检测,并根据药敏结果选择适当的抗菌药物。
OBJECTIVE To study resistance of Enterococcus in clinical isolates to high-level gentamicin（HLG） and investigate drug resistance of these Enterococcus. METHODS Totally 140 strains of Enterococcus were detected resistance to antibiotics by Kirby-Bauer test and agar-screening test. Data were analyzed using WHONET5. 3 software. RESULTS Same result was obtained by two kinds of detecting methods, there were 73 strains of high level gentamicin resistance（HLGR, 52.1 %） and 67 strains of non-HLGR（47.9%）, the resistance rate of HLGR was higher than that of non-HLGR, the isolation rate of vancomycin resistanct Enterococcus was 3. 6%. CONCLUSIONS The most common enterococci causing hospital infection are E. faecalis and E. faecium. The drug resistance rate of E. faecium is higher than that of E. faecalis. It is imperative to select the proper method to detect HLGR of Enterococcus, and select proper antibiotic in terms of antibiotic susceptibility test during clinical therapy.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第19期2607-2609,共3页
Chinese Journal of Nosocomiology
关键词
肠球菌属
耐药性
高浓度庆大霉素
Enterococcus
Drug resistanee
High-level gentamicin
