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鲍氏不动杆菌的耐药性分析及临床对策 被引量:6

Antimicrobial Resistance of Acinetobacter baumannii and Clinical Strategies
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摘要 目的研究鲍氏不动杆菌的耐药性。方法收集2003年1月-2006年12月医院细菌室分离的鲍氏不动杆菌,采用琼脂扩散法作敏感试验。结果4年共分离鲍氏不动杆菌548株,分布在重症监护病房(ICU)130株(23.7%),外科190株(34.7%),内科168株(30.7%),急诊科60株(10.9%);痰标本分离的鲍氏不动杆菌最多见,占78.5%,其次为伤口分泌物,鲍氏不动杆菌的分离率在4年内逐年增加;鲍氏不动杆菌对多种抗菌药物的耐药率均较高,ICU分离菌株耐药率较普通病房明显增高,除对亚胺培南、环丙沙星敏感率较高外,对其他抗菌药物的耐药率均>50%。结论鲍氏不动杆菌对多种抗菌药物耐药,且以ICU分离株最为明显,应引起高度重视。 OBJECTIVE To analyze the antimicrobial resistance of Acinetobacter baumannii. METHODS A. baumannii was collected in our hospital from Jan 2003 to Dec 2006. Antimicrobial susceptibility testing was performed by disk-diffusion method. RESULTS A total of 548 A. baumannii were collected during 4 years. Of these isolates, 130(23.7 %) strains were from intensive care unit (ICU), 190 strains (34. 7%) from surgical, and others from medical and emergency departments. Most of strains(78.5%) were isolated from sputum, next from wound. The prevalence of A. baumannii was increasing during last 4 years. Results of susceptibility test showed that imipenem was the most active antibiotic against A. baumannii. The resistance rates were high to most antibiotics. Most of the resistant strains was from the ICU and the general ward differentand had significant difference. More than 50% of isolates were resistant to all antimicrobial agents tested except imipenem and ciprofloxacin in ICU. CONCLUSIONS The prevalence of A. baumannii is increasing. A. baumannii isolates show high resistance to multiple antibiotics, especially in ICU.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2009年第19期2644-2646,共3页 Chinese Journal of Nosocomiology
关键词 鲍氏不动杆菌 耐药性 Acinetobacter baumannii Antimicrobial resistance
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  • 1任南,吴安华,冯丽,文细毛,易霞云,吕一欣,龚瑞娥,黄勋,王曼平.住院患者抗菌药物临床应用横断面调查[J].中华医院感染学杂志,2006,16(9):1048-1050. 被引量:209
  • 2袁咏梅,顾平,丁晓萍.重症监护病房医院感染病原菌分布及耐药性分析[J].中华医院感染学杂志,2006,16(12):1426-1428. 被引量:67
  • 3郭玲娇,李招云,张颖,陈贤君.鲍氏不动杆菌感染及耐药性分析[J].中华医院感染学杂志,2007,17(2):216-217. 被引量:35
  • 4Hanberger H,Diekema D, Fluit A, et al. Surveillance of antibiotics resistance in European ICUs[J]. Hosp Infect, 2001,48 : 161-176.
  • 5Jones R N. Resistance patterns among nosocomial pathogens: Trends over the past few years[J]. Chest,2001,119: 397-404.
  • 6Montero A, Corbella X, Ariza J. Clinical relevance of Acinetobacter baumannii ventilator-associated pneumonia[J]. Crit Care Med,2003,31:2557-2559.
  • 7Cooperstock M S. Inactivation of endotoxin by polymyxin B [J]. Antimicrob Agents Chemother, 1974,6(4) : 422-425.
  • 8Li J, Nation R L, Turnidge J D, et al. Colistin: the reemerging antibiotic for multidrug-resistant Gram-negative bacterial infections[J]. Lancet Infect Dis, 2006,6: 589-601.
  • 9Hancock R E. Peptide antibiotics[J]. Lancet, 1997,349: 418- 22.
  • 10Hermsen E D, Sullivan C J,Rotschafer J C. Polymyxins: pharmacology, pharmacokinetics, pharmacodynamics, and clinical applications[J]. Infect Dis Clin North Am, 2003,17: 545-62.

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