摘要
微RNA(microRNA,miR)是一种内源性的、长度约为22nt的小非编码RNA,在转录后水平对基因的表达具有重要调节作用。miR在神经系统中大量表达,与神经系统的功能如发育分化、突触可塑性、生物钟调节等密切相关。miR的异常表达可能参与阿尔茨海默病、帕金森氏病等神经系统疾病的发生和发展。miR还可成为某些疾病的治疗靶点。因此,miR日益成为研究神经系统功能和疾病的重要工具。
MicroRNA （miR） is about 22 nucleotide endogenous small non-coding RNA that plays an important role in regulation of gene expression at posttranscriptional level. Numerous miRs are expressed in the nervous system, and are associated with the functions of nervous system, such as brain development and neuron differentiation, synaptic plasticity, the modulation of circadian-clock, etc. Abnormal expression of miR is linked with various nervous system diseases, such as Alzheimer＇s disease and Parkinson＇s disease, miR may also serves as potential therapy targets in some diseases. Therefore, miR is an important tool for the study on the functions and diseases of nervous system.
出处
《生命的化学》
CAS
CSCD
北大核心
2009年第5期735-738,共4页
Chemistry of Life
基金
广东省自然科学基金(07005145
9151051501000053
8451051501000070)资助
关键词
微RNA
神经系统功能
神经系统疾病
microRNA
function of nervous system
nervous system disease
