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JAK/STAT信号通路与急性肺损伤 被引量：2

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摘要 JAK（Janus activated kinasel-STAT（signal transducers and activators of transcription）信号转导通路能被细胞因子，激素或生长因子等激活，从而诱导许多生物反应。LPS处理小鼠后，STAT迅速被激活，在肺中，STATs的激活比急性肺损伤（ALI）症状出现的早．说明STAT在诱发炎性反应中可能扮演重要的角色。JAK/STAT的负调控对关闭细胞因子或生长因子等信号是非常重要的，本文将从JAK/STAT负调控的研究进展以及与AU的关系等方面做一阐述。
作者 周敏 周宁
机构地区 江苏食品职业技术学院生物工程系
出处 《现代医药卫生》 2009年第21期3291-3293,共3页 Journal of Modern Medicine & Health
关键词 JAK/STAT信号通路 急性肺损伤 信号转导通路 细胞因子 生长因子 STATS 生物反应 炎性反应
分类号 R965.1 [医药卫生—药理学] R563 [医药卫生—呼吸系统]
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参考文献22

  • 1Mariano Severgnini ,Satoe Takahashi, Liliana M. Activation of the STAT pathway in acute lung injury[J].Am J Physiol Lung Cell Mol Physiol,2004,286:L1282.
  • 2Mariano Severgnini, Satoe Takahashi, Powen Tu, et al. Inhibition of the Src and Jak Kinase.Protects against Lipopolysaccharide-induced Acute Lung Injury[J]. American Journal of Respiratory and Critical Care Medicine, 2005,171:858.
  • 3Hongwei Gao, Ren-Feng Guo, Cecilia L, et el. Stat3 Activation in Acute Lung Injury[J].The Journal of Immunology, 2004, 172:7703.
  • 4Espert L, Dusanter-Fourt I, Chelbi-Alix MK.Negative regulation of the JAK/STAT: pathway implication in tumorigenesis. [J]. BULLETIN DU CANCER,2005,92(10): 845.
  • 5Jason S, Rawlings,Kristin M ,et al.The JAK/STAT signaling pathway. [J].Journsl of Cell Science ,2004,117 : 1251.
  • 6Yuhong Chen, Rerrren Wen,Shoua Yang, et al.ldentification of Shp-2 as a Stat5A Phosphatase[J].Biol Chem, 2003,278 (19):1652.
  • 7Tracey J, Mitchelll, Susan John, et al.Signal transducer and activator of transcription (STAT) signaling and T-cell lymphomas[J].Immunology, 2005,114: 301.
  • 8Ten Hoeve J ,Jesus Ibarra-Sanehez M, Fu Y, et al.Identification of a nuclear Statl protein tyrosine phosphatase[J].Mol Cell Biol, 2002, 22:5662.
  • 9Gyeong-Hun Baeg, Rui Zhou,Norbert Perrinmon.Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila [J]. GENES & DEVELOPMENT,2005,19:1861.
  • 10Alexander WS, Hilton DJ.The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response[J].Annu Rev Immunol, 2004,22 : 503.

同被引文献16

  • 1Arbouzova N I,Zeidler M P.JAK/STAT signalling in Drosophila:in-sights into conserved regulatory and cellular functions [J].Develop-ment,2006,133(14):2605-2616.
  • 2Gilbert M M,Weaver B K,Gergen J P,et al.A novel functional acti-vator of the Drosophila JAK/STAT pathway,unpaired2,is revealed byan in vivo reporter of pathway activation[J].Mech Dev,2005,122(7/8):939-948.
  • 3Chen H W,Chen X,Oh S W,et al.Mom identifies a receptor for theDrosophila JAK/STAT signal transduction pathway and encodes a pro-tein distantly related to the mammalian cytokine receptor family[J].Genes Dev,16(3):388-398.
  • 4Binari R,Perrimon N.Stripe-specific regulation of pair-rule genesby hopscotch,a putative Jak family tyrosine kinase in Drosophila[J].Genes Dev,1994,8(3):300-312.
  • 5Yan R,Small S,Desplan C,et al.Identification of a Stat gene thatfunctions in Drosophila development[J].Cell,1996,84 (3):421-430.
  • 6Baeg G H,Zhou R,Perrimon N.Genome-wide RNAi analysis ofJAK/STAT signaling components in Drosophila[J].Genes Dev,2005,19 (16):1861-1870.
  • 7Wormald S,Hilton D J.Inhibitors of cytokine signal transduction[J].J Biol Chem,2004,279(2):821-824.
  • 8Usacheva A,Kotenko S,Witte M M,et al.Two distinct domainswithin the N-terminal region of Janus kinase 1 interact with cyto-kine receptors[J].J Immunol,2002,169(3):1302-1308.
  • 9Rawlings J S,Rosier K M,Harrison D A.The JAK/STAT signalingpathway[M].2004:1281-1283.
  • 10程廷才,夏庆友,许平震,谭祥,方婷,向仲怀.家蚕免疫相关基因和信号途径的鉴定和比较分析(英文)[J].昆虫学报,2009,52(3):235-245. 被引量：14

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现代医药卫生
2009年 第21期

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