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sp600125对乙醛刺激的HSC—T6细胞株的影响 被引量：2

Effects of sp600125 on acetaldehyde stimulated hepatic stellate cells
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摘要 肝星状细胞（HSC）的增殖与凋亡在肝纤维化的形成中起作十分重要的作用。乙醛刺激的HSC增殖是导致酒精性肝纤维化发生的关键因素。丝裂原激活蛋白激酶（MAPK）包括细胞外调节蛋白激酶、c-Jun氨基末端激酶和p38，是HSC激活、增殖并导致肝纤维化发牛的主要信号传导通路之一，其中，JNK信号传导通路参与了细胞增殖、分化以及凋亡的调控。我们既往对肝纤维化发病机制的研究结果证实，乙醛刺激的HSC中，p-JNK水平随JNK信号传导通路特异阻断剂sp600125浓度增加而减少。
作者 唐文 蒋明德 李小安
机构地区 成都军区总医院感染科 成都军区总医院消化内科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2009年第10期792-793,共2页 Chinese Journal of Hepatology
关键词 肝星状细胞 胶原 细胞凋亡 细胞增殖 SP600125 Hepatic stellate cells Collagen Apoptosis Cell proliferation sp600125
分类号 R575.2 [医药卫生—消化系统]
  • 相关文献

参考文献11

  • 1Anania FA, Womack L, Jiang M, et al. Aldehydes potentiate alpha (2)(1) collagen gene activity by JNK in hepatic stellate cells. Free Radic Biol Med, 2001, 30: 846-857.
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  • 3钟显飞,蒋明德,马洪德,曾维政,李小安.JNK信号通路对乙醛刺激的大鼠肝星状细胞增殖的影响[J].西南国防医药,2004,14(4):350-353. 被引量：7
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二级参考文献8

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共引文献6

同被引文献2

  • 1Kristine C. Nyhan,Noel Faherty,Gregg Murray,Laurence Berubé Cooey,Catherine Godson,John K. Crean,Derek P. Brazil.Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells[J].BBA - Molecular Cell Research.2010(12)
  • 2Constantin Jotzu,Eckhard Alt,Gabriel Welte,Jie Li,Bryan T. Hennessy,Eswaran Devarajan,Srinivasalu Krishnappa,Severin Pinilla,Lilly Droll,Yao-Hua Song.Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors[J].Analytical Cellular Pathology / Cellular Oncology.2010(2)

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中华肝脏病杂志
2009年 第10期

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