摘要
目的:比较奥沙利铂(L-OHP)联合卡培他滨(Cap)或氟尿嘧啶(5-FU)/甲酰四氢叶酸钙(CF)治疗晚期胃癌的近期疗效和安全性。方法:72例患者随机分为两组,A组采用XELOX方案:即L-OHP 130mg/m^2静脉滴注2h,第1天,Cap每天2 000mg/m^2,分两次口服,连用14天,21天为1个周期。2个周期后评价疗效;B组采用FOLFOX4方案:即L-OHP 85mg/m^2,静脉滴注2h,第1天;CF 200mg/m^2,静脉滴注2h,第1、2天;5-FU 400mg/m^2,快速静脉滴注,第1、2天,600mg/m^2,持续静脉滴注22h,第1、2天,每2周为一个周期。4个周期后评价疗效。结果:入组观察72例,包括初治患者42例,复治患者30例。总有效率(RR)为45.8%(33/72),其中XELOX方案组RR为47.2%(17/36),中位疾病进展时间(TTP)为27周;FOLFOX4组RR为44.4%(16/36),中位TTP为23周。两组RR和TTP比较差异无统计学意义(P>0.05)。患者不良反应主要为胃肠道反应、周围神经毒性及骨髓抑制等,无治疗相关性死亡。结论:L-OHP联合Cap治疗晚期胃癌疗效较好,不良反应可耐受。
Objective： To evaluate the efficacy and safety of oxaliplatin （L-OHP） plus Capecitabine （Xeloda） and oxaliplatin （L-OHP） plus 5-fluorouracil （5-FU）/Calcium folinate （CF） in the treatment of advanced gastric cancer. Methods： A total of 72 patients with advanced gastric cancer were randomly assigned to receive the regimen of XELOX （n=36） or FOLFOX4 （n=36）. Group A underwent the XELOX regimen consisting of oxaliplatin 130 mg/m^2 on day 1, Capecitabine 2000 mg/m^2, bid, with the first dose on the evening of day 1 and the last dose on the morning of day 15, repeated every 3 weeks. Group B underwent the FOLFOX4 regimen consisting of oxaliplatin 85 mg/m^2 on day 1, CF 200 mg/m^2 infusion in 2 hours followed by bolus 5-FU 400 mg/ m^2 and a 22-hour infusion of 5-FU 600 mg/m^2, repeated for 2 consecutive days every 2 weeks. Results： All 72 patients were evaluated for treatment efficacy. The overall response rate was 45.8% （33/72）. The response rate was 47.2% （17/36） for group A and 44.4% （16/36） for group B （P〉0.05）. The median time to progression （TTP） in group A and group B was 27 weeks and 23 weeks （P〉0.05）, respectively. The most common adverse reactions were gastrointestinal reaction, peripheral neuropathy and marrow suppression. No treatment related death occurred. Conclusion： The regimen of Capecitabine （Xeloda） plus oxaliplatin （L-OHP） is effective for treating advanced gastric cancer with tolerable adverse effects.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2009年第18期1044-1046,共3页
Chinese Journal of Clinical Oncology
关键词
卡培他滨
奥沙利铂
氟尿嘧啶/甲酰四氢叶酸钙
晚期胃癌
联合化疗
Capecitabine （Xeloda）
Oxaliplatin （L-OHP）
5-fluorouracil （5-FU）/calcium folinate （CF）
Advanced gastric cancer
Combinated chemotherapy
