摘要
目的评价甲硝唑减轻痔切除术后疼痛的效果。方法计算机检索中国期刊全文数据库(1994～2009.3)、中国生物医学文献数据库(1978～2009.3)、中文科技期刊全文数据库(1989～2009.3)、数字化期刊全文数据库(1997～2009.3)、PubMed(1966～2009.3)、Cochrane Library(2009年第1期)、EMbase(1900～2009.3)、SCI(1974～2009.3),同时手检相关专业期刊,纳入甲硝唑与安慰剂比较用于痔切除术后的随机对照试验。按Cochrane系统评价手册4.2.6推荐的评价标准评价纳入研究质量,并采用Cochrane协作网提供的RevMan4.2.10软件进行Meta分析。结果共纳入7个研究,包括553例患者。Meta分析结果显示,甲硝唑组减轻痔切除术后疼痛效果优于安慰剂组,额外服用镇痛剂剂量少于对照组,同时可有效减轻患者术后第一次排便的疼痛分数。结论甲硝唑可有效减轻痔切除术后疼痛,并可减少术后额外服用镇痛剂剂量。但鉴于纳入研究样本量小,论证强度受到一定限制,上述结果有必要进一步开展高质量、大样本随机临床对照试验予以证实。
Objectives To evaluate the effect of metrinidazole treatment after conventional hemorrhoidectomy pain in patients with third and fourth degree hemorrhoids. Methods We searched the Cochrane Library （Issue 1 2009）, PubMed （1966 to March 2009）, EMbase （1974 to March 2009）, SCI （1974 to March 2009）, CBM （1978 to March 2009）, CNKI （1994 to March 2009）, and VIP （1989 to March 2009） to identify randomized controlled trials or quasirandomize controlled trials of metronidazole versus placebo for treating post hemorrhoidectomy pain. We evaluated the quality of the included studies by using the Handbook 4.2.6 recommend standards and analyzed data using the Cochrane Collaboration＇s RevMan 4.2.10. Results We included seven randomized controlled trials or quais-randomized controlled trials （n=553）. Meta-analyses showed that there were statistical differences between metronidazole and placebo in pain after hemorrhoidectomy and the use of an additional dose of analgesia. Conclusions The current evidence shows that metronidazole relieves the pain after conventional hemorrhoidectomy and reduces the additional used of analgesics. Further high quality, large sample randomized controlled trials should be carried out.
出处
《中国循证医学杂志》
CSCD
2009年第9期979-984,共6页
Chinese Journal of Evidence-based Medicine
基金
兰州大学循证医学中心"循证医学研究生创新基金"(2008LDEBM-Y)
关键词
甲硝唑
痔
痔切除术
疼痛
系统评价
Metronidazole
Hemorrhoids
Hemorrhoidectomy
Pain
Systematic review
