摘要
测定３０例高血压病（ＥＨ）患者和１６例正常血压（ＮＴ）对照组禁食及７５ｇ葡萄糖负荷后３０，６０，１２０ｍｉｎ血浆葡萄糖和胰岛素浓度，红细胞内钠、钾、镁离子（Ｎａ＋，Ｋ＋，Ｍｇ２＋）浓度。结果表明ＥＨ患者禁食３０，６０ｍｉｎ血浆葡萄糖和禁食３０，６０，１２０ｍｉｎ血浆胰岛素浓度和Ｎａ＋显著高于ＮＴ对照组，而Ｋ＋、Ｍｇ２＋显著低于ＮＴ对照组。简单相关分析显示ＥＨ组空腹血浆胰岛素（ＦＩＮＳ）与体重、体重指数（ＢＭＩ）、臀围显著正相关、胰岛素曲线下面积（ＡＵＣ）与年龄、ＢＭＩ正相关。研究提示ＥＨ患者存在胰岛素抵抗（ＩＲ）。
Plasma glucose,insulin, erythrocyte sodium,potassium and magnesium(Na +,K +,Mg 2+ ) levels were determined in 30 patients with essential hypertension (EH) and 16 normotensive (NT) controls of matched gende age. The results demonstrate the both fasting followed by 30 and 60 minutes of plasma glucose and fasting followed by 30, 60 and 120 minutes of plasma insulin responded to a 75g oral glucose loaded,and Na + levels were significantly higher in patients with EH than in NT controls. The K + and Mg 2+ levels were significantly lower in patients with EH than in NT controls. The fasting insulin (FINS) significantly positively correlated with weight, body mass index (BMI) and hip. The area under the insulin curve (AIC) significantly positively correlated with age and BMI in patients with EH. The present study suggests that IR exists in patients with EH,and it may contribute to hypertension by influencing intracellular cation generation.
出处
《中国现代医学杂志》
CAS
CSCD
1998年第11期11-12,15,共3页
China Journal of Modern Medicine
关键词
高血压病
胰岛素抵抗
红细胞
钠、钾、镁离子
Essential hypertension
Insulin resistance
Erythrocyte
Sodium
Potassium
Magnesium
