摘要
目的探讨高血压病（ＥＨ）辨证分型与胰岛素抵抗（ＩＲ）的关系。方法用葡萄糖氧化酶法及放免双抗体法测定空腹及服糖后１ｈ、２ｈ血糖、血胰岛素值，并计算胰岛素敏感指数（ＩＳＩ）。结果ＥＨ及其肝火亢盛、阴虚阳亢组各时点胰岛素及服糖后１ｈ、２ｈ血糖较正常对照组明显升高（Ｐ＜０．０５～０．０１），ＩＳＩ明显降低（Ｐ＜０．０５～０．０１）。且此两证型组分别与阴阳两虚、痰湿壅盛组比较，这种升高和降低也有统计学意义（Ｐ＜０．０５～０．０１）。而阴阳两虚、痰湿壅盛组除后者服糖后１ｈ血糖、胰岛素值较正常组有显著升高（Ｐ＜０．０５）外，余各指标较正常组均无显著差异。结论ＥＨ患者存在ＩＲ，其证侯特点为肝火亢盛、阴虚阳亢。
Objective:Research for the connection between the differentiation of essential hypertension (EH) and insulin resistance (IR).Methods:With the methods of glucoseoxidace and means of radioimmynoassay,determine the blood glucose and blood insulin of fasting and 1hour,2hours after eating sugar respectively,calculate insulin sensitivity index(ISI).Results:To EH group and Liver Fire Hyperactivity,Hyperactivity of Yang due to Yin Deficiency group,insulin of every and blood glucose of 1hour,2hours after eating sngar respectively are raise more obviously than those of control group ( P <0 05～0 01),ISI is declined more notably ( P <0 05～0 01),then these two groups are comparecl with the group of Deficiency of Both Yin and Yang,Abundant Phlegm Dampness,the raising and declination are also positive in statistics.But for the group of Deficiency of Both Yin and Yang,Abundant Phlegm Dampeness,except thet the blood glucose and blood insulin of 1hour after eating sngar are raised more obviously than those of control group,other index have no dramatic difference from those of control group.Conclusion:Patients with EH have IR at the sametime,the character of syndrome is Liver Five Hyperactivity and Hyperactivity of Yang Due to Yin Deficiency,inferring that IR may be the objective base of the differentiation of EH.
出处
《中国中医基础医学杂志》
CAS
CSCD
1998年第11期37-39,共3页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
高血压
辨证分型
胰岛素抵抗
诊断
hypertension,classification of syndrome differentiation,insulin resistance.
