摘要
目的测定宁夏道地药材铁棒锤小鼠半数致死量（LD50）。方法50只小鼠随机分为5组，每组10只，雌雄各半灌胃给予铁捧锤总浸膏1229mg／kg、860mg／kg、602mg／kg、421mg／kg、295mg／kg5个剂量，连续观察14d，记录各组小鼠症状，以小鼠急性死亡率为指标，计算铁棒锤的LD50和LD50的95％可信区间结果铁棒锤总浸膏的LD50为624mg／kg，其95％可信区间为502～774mg／kg结论铁棒锤按毒性分级标准属于中等毒性。
Objective To determinate the median lethal concentration dose in mice from Aconitum pendulum of Genuine Medicinal Materials in Ningxia. Methods Fifty mice were divided into 5 groups randomly, ten rats in each group, half male and half female. Each group was received different doses of total extract from Aconitum pendulum （1229 mg/kg,860 mg/kg,602 mg/kg,421 mg/kg,295 mg/kg ） by gastric perfusion. And then to observe continuously for 14 days, recorded symptoms of mice .According to the index of acute mortality of mice, calculated median lethal concentration dose and 95% confidence interval. Results The median lethal concentration dose of total extract from Aconitum pendulum was 624 mg/kg, and 95% confidence interval was 502-774 mg/kg. Conclusion Aconitum pendulum belongs to medium toxicity according to toxicant classification standard.
出处
《现代中药研究与实践》
CAS
2009年第5期43-44,共2页
Research and Practice on Chinese Medicines
基金
宁夏自然科学基金项目编号:NZ0780
关键词
铁棒锤
LD50
毒性
Aconitum pendulum
median lethal concentration dose
anti-inflammatory
toxicity
