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康莱特加同步放化疗治疗局部晚期非小细胞肺癌临床研究 被引量:3

Kanglaite injection combined with concurrent chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer
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摘要 目的:观察康莱特注射液(KLT)联合同步放化疗对局部晚期非小细胞肺癌的治疗效果。方法:48例局部晚期非小细胞肺癌患者,随机分为两组,综合组:25例,采用盖诺+顺铂方案同步放化疗,放疗予常规分割,2Gy/f,总量56~60Gy,同时加用康莱特注射液200ml/d静脉滴入,21天为1个疗程,共2个疗程。对照组:23例,采用盖诺+顺铂方案同步放化疗。2疗程后评价疗效,通过KPS评分、体重变化观察生存质量改善情况。结果:两组完全缓解率分别为20.0%和13%(P>0.05);有效率分别为80.0%和69.5%(P>0.05);综合组3级以上骨髓抑制发生率为40.0%,而对照组为69.6%(P<0.05);综合组3级以上消化道不良反应发生率为8.0%,对照组为34.8%(P<0.05);综合组无3级以上放射性肺炎发生,而对照组为4.4%(P>0.05);综合组3级以上放射性食管炎发生率16.0%,对照组为43.5%(P<0.05);综合组治疗前后KPS评分及体重评分明显高于对照组(P<0.05)。结论:康莱特联合同步放化疗可以减轻放化疗引起的胃肠道反应,减少3级以上骨髓抑制和3级以上放射性食管炎的发生,使患者的生存质量得到改善,但从疗效分析,NP方案同步放化疗是否联合使用康莱特,无统计学差异。 Objective:To evaluate the clinical toxicity and efficacy of Kanglaite injection combined with concurrent chemora-diotherapy in the treatment of locally advanced non-small cell lung cancer.Methods:Forty-eight patients with locally advanced non-small cell lung cancer were randomized into two groups.The combination group received chemotherapy of NVB+DDP regimen,radio-therapy was given with conventional fraction in 2Gy per fraction and five fractions per week.The total tumor doses were 56~60Gy.Combined with Kanglaite injection 200 ml/d for consecutive twenty-one days for two courses, and the control group was chemoradiother-apy only. Toxicities and effects were evaluated according to the criteria of WHO. Results; The CR in combination group and control group were 20.0% and 13% ,respectively(P〉0.05). Response rate of combination group was 80.0% and 69.5% in control group (P〉0.05). Grade 3-4 leukocytopema,grade 3--4 digestive system and grade 3-4 radiation esophagitisin combination group and control group were 40.0 % , 8.0 % , 16.0 % and 69.6 % , 34.8 % , 43.5 %, respectively(P〈0.05). KPS and bodyweight score significantly increased in combination group after the combinedtreatment (P〈0.05). Conclusions: Kanglaite injection combined with concurrent chemoradiotherapy could relieve side effects of chemo radiotherapy in the treatment of locally advanced non-small cell lung cancer,and improved life quality. Kanglaitc could increase effectiverate of locally advanced non small cell lung cancer combined with concurrent chemoradiothrapy.
出处 《中国冶金工业医学杂志》 2009年第5期512-514,共3页 Chinese Medical Journal of Metallurgical industry
关键词 康莱特注射液 同步放化疗 非小细胞肺癌 Kanglaite injection Concurrent chemoradiotherapy Non-small cell lung cancer
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  • 1Kim TY, Yang SH, Lee SH, et al. A phase III randomized trial of combined chemoradiotherapy versus radiotherapy alone in locally advanced non small cell lung cancer[J]. Am J Clin Oncol, 2002, (25):238-243.
  • 2Sim S, Rosenzweig KE, Schindelheim R, et al. Induction chemo2therapy p lus three2dimensional conformal radiation therapy in thedefinitive treatment of locally advanced non-small cell lung cancer[J]. Int J Radiat Oncol Biol Phys, 2001, ( 5 1 ) : 660-665.
  • 3林育红,王芳,陈萍,张俊丽.康莱特注射液联合CAP方案治疗晚期非小细胞肺癌临床疗效观察[J].肿瘤防治杂志,2004,11(6):647-649. 被引量:29
  • 4陈东福.肺癌[A].见:殷蔚伯 谷铣之主编.肿瘤放射治疗学[C].北京:中国协和医科大学出版社,2002.623-649.
  • 5徐素俊,石玉生,宋海春,陈龙华.大分割适形放疗和常规分割放疗对非小细胞肺癌原发灶的疗效分析[J].第一军医大学学报,2002,22(10):937-938. 被引量:24
  • 6李宝生.陈学明,孔令东,等.肺癌,见:于金明,殷蔚伯,李宝生主编.肿瘤精确放射治疗学.山东:山东科学技术出版社,2003:682-683.

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