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不同镇痛模式对行宫颈癌根治术病人细胞免疫功能的影响

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摘要 目的探讨不同镇痛模式对行宫颈癌根治术病人细胞免疫功能的影响。方法择期行宫颈癌根治术病人60例,随机分为两组(n=30):Ⅰ组术后行病人自控硬膜外镇痛(PCEA),Ⅱ组术后行病人自控静脉镇痛(PCIA)。两组分别于麻醉前T0(Prean),切皮时T1(opo),切皮后90min T2(Op90),手术结束时T3(Postop0),术后4小时T4(Post4),术后24小时L(Post24)抽取肘静脉血用ELISA法测定血浆内细胞因子IL-2、IL-6的水平。结果Ⅰ组IL-2的表达在T4比T0明显升高,Ⅱ组IL-2的表达在T4、T5显著降低(P〈0.01);Ⅰ组在T4、T5的IL-2水平比Ⅱ组明显升高(P〈0.05)。两组IL-6的表达在T2、T3、L、L与T0相比均显著升高(P〈0.01),两者间没有差异。结论术后硬膜外阻滞镇痛模式能够改善创伤应激带来的细胞免疫功能的抑制。
作者 林昭明 李伟
出处 《实用肿瘤学杂志》 CAS 2009年第5期473-475,共3页 Practical Oncology Journal
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