摘要
目的评价腹腔镜Nissen胃底折叠术(LNF)治疗胃食管反流病(GERD)的安全性。方法计算机检索MEDLINE、EMBASE、PubMed、CBM、CNKI及Cochrane图书馆;手工检索有关中文杂志。纳入LNF与传统开腹Nissen胃底折叠术(ONF)治疗GERD的前瞻性随机对照试验(RCT),用RevMan4.2.2软件进行统计分析。结果共纳入6个RCT,包括442例患者,无一例术后死亡病例,Meta分析结果显示,LNF与ONF相比手术并发症发生率低,差异有统计学意义(P<0.05)。结论与ONF相比LNF治疗GERD有更高的手术安全性,尚有待进一步开展大样本高质量的RCT予以证实。
Objective To evaluate the safety of laparoscopic Nissen fundoplication（LNF） for gastroesophageal reflux disease（GERD）. Methods The electronic databases（MEDLINE, EMBASE, PubMed, Cochrane Library, CBM, CNKI） were searched, and relevant chinese articles were also sought manually. The randomised controlled trails（RCTs） on LNF vs open nissen fundoplication（ONF） were identified. RevMan 4.2.2 software was used for statistical analysis. Results Six RCTs （which comprised 442 patients） on LNF vs ONF were included. No death was observed after the procedures in both groups. The result of Meta-analysis showed that there was statistical significant difference in incidence of complications between LNF and ONF（P〈0.05）. Conclusion LNF is more safe than the open procedure for GERD. RCTs with large series and high quality are required to confirm this argument.
出处
《中华普通外科学文献（电子版）》
2009年第5期58-60,共3页
Chinese Archives of General Surgery(Electronic Edition)
基金
广东省科技计划项目资助(2005B31201015)
关键词
胃底折叠术
腹腔镜外科手术
胃食管反流
并发症
META分析
Fundoplication
Laparoscopic surgery procedures
Gastroesophageal reflux
Complications
Meta-analysis
