摘要
目的在WinGlucofacts Professional糖尿病管理软件配合下,比较输液泵持续皮下输注胰岛素(CVⅡ)与胰岛素泵持续皮下输注胰岛素(CSⅡ)及四次皮下胰岛素注射(MSⅡ)治疗初发糖尿病的疗效及安全性。方法选择60例初发2型糖尿病患者,随机分为3组,各20例。CVⅡ组患者采用输液泵持续静脉输注超短效胰岛素,餐前追加大剂量治疗;CSⅡ组患者采用胰岛素泵持续皮下输注超短效胰岛素,餐前追加大剂量治疗;MSⅡ组患者采用四次皮下注射胰岛素治疗。应用WinGlucofacts Professional软件管理3组患者的血糖。比较3组患者治疗后的血糖控制情况、胰岛素使用量及安全性。结果3组患者治疗后空腹血糖、餐后2h血糖水平间差异无统计学意义(P>0.05),均得到较好的控制。CVⅡ组、CSⅡ组血糖达标时间(5.5±0.7)d和(6.0±0.8)d、胰岛素总量(0.68±0.16)U.kg-1.d-1和(0.63±0.23)U.kg-1.d-1、低血糖发生频率(0.50±0.46)次/人和(0.55±0.51)次/人及空腹C肽(2.18±0.58)μg/L和(2.23±0.67)μg/L、餐后2hC肽水平(8.02±0.79)μg/L和(7.86±0.68)μg/L与MSⅡ组分别为(10.3±0.4)d、(0.89±0.25)U.kg-1.d-1、(0.85±0.37)次/人、(1.56±0.94)μg/L和(6.01±0.92)μg/L比较,差异均有统计学意义(P<0.05),CVⅡ组血糖达标时间与CSⅡ组比较,差异亦有统计学意义(P<0.05)。结论CVⅡ与CSⅡ一样能模拟胰岛素的生理分泌模式,较MSⅡ能更快、更安全、更有效地控制高血糖,并能使胰岛β细胞功能得到更好的恢复。
Objective To observe,coordinated with WinGlucofacts Professional diabetes management software,the effect and safety of infusion pump continuously infusing insulin（CVⅡ）,insulin pump continuously infusing insulin（CSⅡ） and 4 subcutaneous insulin injections（MSⅡ）.Methods Sixty primary type 2 diabetic patients were divided randomly into three groups,20 in each.CSⅡ group were infused continuously with short-acting insulin with infusion pump,and given additional high-dose before meal.MSⅡ group were treated with subcutaneous insulin,4 times.WinGlucofacts Professional software was used to manage blood glucose of three groups.The blood glucose control,insulin usage and safety were compared after treatment.Results After the treatment,fasting blood glucose（FPG）,2-hour postprandial blood glucose（2 hPG） decreased significantly in three groups（P〈0.001） ;the average duration of treatment,insulin dosages and hypoglycemia incidence were lower in group CVⅡ than in MSⅡ（P〈0.05）;fasting C-peptide（FC-P） and 2-hour postprandial C-peptide（2 hFC-P） were much higher in group CVⅡ than in MSⅡ（P〈0.01）,and there was not significant difference in the above parameters between CVⅡ and CSⅡ（P〉0.05）.Conclusion CSⅡ,simulating physiological insulin secretion pattern as CSⅡ,can control hyperglycemia more quickly,safely and effectively,and can make pancreatic β-cell function recover better.
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第20期1841-1843,共3页
Chinese General Practice
