摘要
目的研究活血化瘀中药制剂腰痛康治疗血瘀型腰痛的作用机理。方法把40只成年白兔制成模拟神经根炎，随机分为空白对照组、腰痛康煎剂组、腰痛康膏剂组、阳性对照药腰痛宁组。给药的3个组自造模术后第2天开始每天灌胃给药。于给药第7天和第15天采血作血液流变学检查，于给药第10天采血作血清NO浓度检测。结果与空白对照组相比，腰痛康煎剂组和膏剂组给药7天时其血浆粘度、纤维蛋白原、血沉有不同程度的降S氏；给药15天时其全血粘度、红细胞聚积有不同程度的降低；给药10天时其血清NO显著降低。结论腰痛康可以改善血液的粘浓状态，降低血清NO浓度，促使神经根炎症的消除和组织修复，从而达到止痛的效果。
Aim To study the mechanism of the effectiveness of Yao Tong Kang (YTK), a traditional Chinese herbal preparation, for treating blood stasis type lumbago. Methods The simulated radicular neuritis models were made in 40 rabbits, and divided into blank control group, YTK decoction treated group, YTK soft extract treated group,and Yao Tong Ning treated group. The animals in the last three groups were administered the drugs by gastric perfusion every day from the second day of modeling. At the 7th and 15th day of drug administration, the blood samples were collected for hemorrheological eximination; and at the 10th day of drug administration, the blood samples were taken for serum NO determination. Results in comparison with the blank control group, the plasma viscosity, fibrinogen, and erythrocyte sedimentation rate in YTK decoction and YTK soft extract groups were decreased in different extent at the 7th day of administration, the whole blood viscosity and erythrocyte aggregation were decreased in different extent at 15th day of administration, and the serum NO concentration was significantly decreased at 10th day. Conclusion YTK can improve the viscosity and consistency of blood, decrease the concentration of serum NO and accelerate the elimination of radicular neuritis and repair of injuried tissues, thus achieving the effectiveess of relieving pain.
出处
《中国骨伤》
CAS
1998年第6期13-15,共3页
China Journal of Orthopaedics and Traumatology
关键词
模拟神经根炎
血液流变学
活血化瘀
腰痛康
Simulated radicular neuritis Hemorrheology Serum NO concentration Promotion of blood circulation to remove blood stasis Chinese drugs preparation Yao Tong Kang
