摘要
目的研究单纯的慢性支气管炎和煤工尘肺合并慢性支气管炎患者的ＨＬＡＤＲＢ１等位基因的异同。方法采用顺序特异性引物聚合酶链反应技术，检测了山西省汉族的３７例单纯慢性支气管炎和３３例煤工尘肺合并慢性支气管炎患者的ＨＬＡＤＲＢ１等位基因频率，并与山西省正常人群进行比较分析。结果单纯慢性支气管炎组的ＨＬＡＤＲＢ１１２０Ｘ基因频率明显增高（２４．３％），而煤工尘肺合并慢性支气管炎组的ＨＬＡＤＲＢ１０４０Ｘ基因频率明显增高（２２．７％），其他等位基因频率在３组之间差异无显著性。结论在山西省汉族人群中，ＨＬＡＤＲＢ１１２０Ｘ与单纯慢性支气管炎有关联。
Objective To study the difference in HLA DRB1 allele frequencies between patients with simple chronic bronchitis and with coal worker's pneumoconiosis (CWP) complicated with chronic bronchitis. Methods HLA DRB1 allele frequencies were measured in 37 patients with simple chronic bronchitis and 33 with CWP complicated with chronic bronchitis of Han ethnicity in Shanxi Province using polymerase chain reaction with sequence specific primer, in comparison with those in normal population of the same province. Results Allele frequency of HLA DRB1*120X was 24.32% in those with simple chronic bronchitis, and that of HLA DRB1*040X was 22.73% in those with CWP complicated with chronic bronchitis, significantly increased than that in normal people with both P <0.01. There was no significant difference in other alleles between the three groups. Conclusion It suggests that in Han ethnicity of Shanxi Province HLA DRB1*120X allele frequency is associated with simple chronic bronchitis and that of HLA DRB1*040X is associated with CWP complicated with chronic bronchitis.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1998年第6期346-348,共3页
Chinese Journal of Preventive Medicine
