摘要
为检验Willis环的侧支循环能力,以及在动脉内膜切除手术(CEA)中颈内动脉(ICA)被夹闭前后环内的血液动力学变化情况,利用CT扫描数据以及计算机辅助设计软件建立了某病人的三维Willis环模型,在右侧颈内动脉(RICA)处人为地构建了一系列不同程度狭窄的模型.将血液模拟为非牛顿流体,采用ANSYS-CFX软件对Willis环内的血液稳态流动进行了三维数值模拟.计算结果表明,当狭窄率大于50%时,环内血液重新分配,前交通动脉(ACoA)侧支循环作用比后交通动脉(PCoA)更加重要.在CEA过程中,压力与脑部总血流量成正比.对于ACoA缺失的Wil-lis环,只通过提升压力并不能有效增加脑部供血,术中可以考虑进行分流.研究结果对于临床具有一定的应用价值.
Focusing the capacity of the circle of Willis（CoW） and the cerebral hemodynamic chan-ges before and after clamping internal carotid artery （ICA） during carotid endarterectomy （CEA）, a 3D computational model was developed combining patient-specific CT images with CAD software. A series of different axisymmetric stenosis were artificially inserted in right internal carotid artery （RICA）. Non-Newtonian blood flow in CoW was simulated under steady flow condition by ANSYS-CFX. The results show that cerebral blood flow gets redistributed as the degree of stenosis is greater than 50%. Collateral flow in anterior communicating artery （ACoA） is much more important than that in posterior communicating artery （PCoA）. As cerebral blood flow （CBF） is proportional to blood pressure, raising blood pressure facilitates improving the cerebral blood supply efficiently during the CEA operation. However, while ACoA missing, the blood supply can not be simply maintained by raising blood pressure, a shunt is necessary.
出处
《西安交通大学学报》
EI
CAS
CSCD
北大核心
2009年第10期119-123,共5页
Journal of Xi'an Jiaotong University
基金
国家自然科学基金资助项目(10672131)
教育部留学归国人员科研启动基金资助项目[2006]
