摘要
丙酰左卡尼汀（propionyl levo carnitine,PLC）为左卡尼汀乙酰转移酶刺激剂,能扩张外周微动脉血管,改善微循环。主要用于治疗或改善间歇性跛行状态,还可用于外周动脉病变疾病,同时它还具有延缓某些药物细胞毒性进程的作用。现将最新研究作一综述。
出处
《中国医药指南》
2009年第20期48-49,89,共3页
Guide of China Medicine
参考文献30
-
1Loffredo L, Pignatelli P, Cangemi R, et al. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment[J].J Vasc Surg, 2006,44(3):525-530.
-
2Allegra C, Antignani PL, Schachter I, et al. Propionyl-L-carnitine in Leriche-Fontaine stage Ⅱ peripheral arterial obstructive disease[J]. Ann Vasc Surg,2008,22(4):552-558.
-
3Hiatt WR, Regensteiner JG, Creager MA,et al. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication[J].Am J Med,2001,110(8):616-622.
-
4Barker GA, Green S, Askew CD, et al. Effect of propionyl-L-camitine on exercise performance in peripheral arterial disease[J]. Med Sci Sports Exert, 2001,33(9): 1415 - 1422.
-
5Smith WA, Fry AC, Tscbume LC, et al. Effect of glycine propionyl- L-camitine on aerobic and anaerobic exercise performance[J]. Int J Sport Nutr Exerc Metab, 2008,18(1): 19-36.
-
6Riccioni C, Sarcinella R, Palermo G, et al. Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriehe stage Ⅱ[J].Int Angiol, 2008,27(3):253-259.
-
7zzollini N, Cugini D, Cassis P, et al. Propionyl-L-carnitine prevents early graft dysfunction in allogeneic rat kidney transplantation[J]. Kidney Int, 2008,74(11): 1420-1428.
-
8Origlia N, Migliori M, Panichi V, et al. Protective effect of L-propionylcamitine in chronic cyclosporine-a induced nephrotoxicity[J]. Biorned Pharmacother, 2006,60(2):77-81.
-
9Aleisa AM, Al-Majed AA, Al-Yahya AA, et al. Reversal of cisplatininduced carnitine deficiency and energy starvation by propionyl- L-carnitine in rat kidney tissues.[J] Clin Exp Pharmacol Physiol, 2007,34(12): 1252-1259.
-
10Broderick TL.ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart[J]. Drugs R D, 2008,9(2):83-91.
同被引文献10
-
1陈卓.丙酰左卡尼汀对酒精所致肝损伤小鼠的保护作用[J].中国老年学杂志,2014,34(4):996-997. 被引量：2
-
2Piero MB. Process for preparing R - ( - ) - camitine from S - ( - ) - chlorosuccinic acid or from a derivative thereof [ P ]. US6677476:6 - 8.
-
3Usera AR, Posner GH. Unexpected sterie effects of "remote" alkyl groups on the rate of conjugate additions to alkyl c~, 13 - ethylenic sulfones, sulfoxides, and esters [ J ]. Journal of Organic Chemistry, 2007,72(7) : 2329 -2334.
-
4Hirokazu K, Hiroaki M. Camitine - esters from the mushroom Suillus laricinus [ J 1. Phytochemistrv. 2006.67 : 2676 - 2680.
-
5陈玉玲.氯化丙酰左卡尼汀的合成研究[J].科技创新与应用,2012,2(2):21-21. 被引量：2
-
6张现涛,焦豪妍,沈小钟,索其良.HPLC法测定盐酸丙酰左卡尼汀原料药及其制剂的含量和有关物质[J].中国药房,2012,23(21):1992-1994. 被引量：3
-
7Giuseppe Merra,Giovanni Gasbarrini,Lucrezia Laterza,Marco Pizzoferrato,Andrea Poscia,Franco Scaldaferri,Vincenzo Arena,Francesca Fiore,Achille Cittadini,Alessandro Sgambato,Francesco Franceschi,Antonio Gasbarrini.Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases[J].World Journal of Gastroenterology,2012,18(36):5065-5071. 被引量：1
-
8沈小钟,杨帆,杨燕军,张现涛.盐酸丙酰左卡尼汀注射剂中有关物质及含量的测定[J].中国药业,2012,21(24):43-44. 被引量：1
-
9董梅蓉,肖峰,吴成义,魏伟.盐酸丙酰左卡尼汀片在健康人体中的药代动力学研究[J].安徽医药,2013,17(3):376-380. 被引量：6
-
10宋兴发,孙增先.UPLC法测定注射用左卡尼汀含量[J].海峡药学,2017,29(1):50-51. 被引量：1
-
1崔俊昌.奈替米星[J].中华结核和呼吸杂志,2015,38(6):419-419.
-
2钱永昌.颈痹颗粒的药效学研究[J].中国中医药科技,2007,14(2):84-85. 被引量：1
-
3降血脂、抗动脉粥样硬化药[J].国外科技资料目录（医药卫生）,1997(6):170-170.
-
4唐克建.左卡尼汀的临床应用进展[J].河北联合大学学报（医学版）,2012,14(6):799-801. 被引量：14
-
5刘 萍,边 强.肉碱的临床研究[J].国外医药（合成药．生化药．制剂分册）,2002,23(3):165-167. 被引量：7
-
6唐瑞康.左卡尼汀治疗心血管疾病的临床应用[J].当代医学,2012,18(18):22-24. 被引量：13
-
7石运生,寇文丽,钟瑞亨,王诗章,董茂盛,张利民,闫存根,禹萍,刘钰春,苟晓丽.左旋卡尼汀改善心力衰竭患者能源缺乏作用观察[J].内蒙古医学杂志,2007,39(3):277-278. 被引量：3
-
8陈丹,袁宁,胡又佳,朱春宝,赵文杰,朱宝泉.顶头孢霉乙酰转移酶基因的克隆、表达和活性研究[J].中国抗生素杂志,2006,31(7):395-399. 被引量：3
-
9顾建平,苏浩波.全国第四次外周血管病介入新技术研讨会纪要[J].介入放射学杂志,2005,14(2):186-186.
-
10戴芸,常立功.去甲肾上腺素诱发的家兔肠系膜微血管运动及尼卡地平对其影响[J].中国病理生理杂志,1999,15(2):119-121.
