摘要
目的:评价益心舒胶囊对慢性心力衰竭(CHF)患者的疗效及其对血管紧张素Ⅱ(AngⅡ)和肿瘤坏死因子-α(TNF-α)的影响。方法:将60例CHF患者随机分为治疗组(30例)和对照组(30例)。对照组进行西药常规治疗,包括控制感染、通畅呼吸道、持续低流量吸氧、强心利尿、扩血管、纠正酸碱失衡和电解质紊乱等对症治疗;治疗组加服益心舒胶囊。检测2组患者治疗前、后AngⅡ、TNF-α的血浆含量,详细记录每个患者治疗前、后的心功能程度和心脏超声指标:左室射血分数(LVEF)及A/E值;并选10例健康体检者作为正常对照组。结果:治疗后2组患者血浆AngⅡ、TNF-α含量均显著降低(P<0.01),组间比较治疗组更为显著(P<0.05);心功能级别改善情况治疗组总有效率为93.33%,对照组为80.00%,2组比较具有显著性差异(P<0.05);治疗后2组LVEF值提高、A/E值下降,但以治疗组变化较显著(P<0.01)。结论:益心舒胶囊可以改善CHF患者神经内分泌及细胞因子异常和心功能异常;其与西药配合使用的疗效明显优于单用西药治疗。
OBJECTIVE： To evaluate the curative efficacy of Yixinshu capsule（YXSC） for patients with chronic heart failure（CHF） and its effects on plasma levels of angiotrnsion Ⅱ （Ang Ⅱ） and tumor necrosis factor-alpha （TNF- a）. MET- HODS： 60 patients with CHF were randomly assigned to either treatment group（ n = 30） or control group （ n = 30） ： the control group received conventional symptomatic treatment with western medicines including anti- infection therapy, relieving airway obstruction, continuous low-flow oxygen inhalation, cardiac and diuretic therapy, vasodilator, correcting acid base imbalance and electrolyte disturbances etc; the treatment group received YXSC in combination with the above conventional symptomatic treatment. Plasma levels of Ang Ⅱ and TNF - a in two groups before and after treatment were detected; and the cardiac function and the indexes of echocardiography（LVEF, A/E） of all cases were recorded in detail before and after treat- ment. Meanwhile, 10 healthy subjects served as normal control. RESULTS： After treatment, plasma levels of Ang Ⅱ and TNF-a in both group decreased remarkably（P〈0.01）, much as in the treatment group（P〈0.05）; there were significant differences between the two groups in total effective rate of the improvement of cardiac functional grading （93.33% for treatment group vs. 80.00% for control group, P〈0.05）; LVEF increased but the A/E decreased in both group after treatment, much as in the treatment group（P 〈 0.01） . CONCLUSION： YXSC can improve neuroendoerine and abnormality in cytokine and cardiac function; the addition of YXSC to western medicines achieved better efficacy than western medicines alone for patients with CHF.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第30期2385-2387,共3页
China Pharmacy
