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急性早幼粒细胞白血病的发病机制及治疗进展 被引量：6

Advance in the pathogenesis and treatment of acute promyelocytic leukemia
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摘要 急性早幼粒细胞白血病（APL）是目前发病机制了解最清楚的血液系统恶性肿瘤。维甲酸和三氧化二砷直接针对PML—RARα融合蛋白的治疗使得该疾病成为肿瘤靶向治疗的第一个模型，各种新型治疗方案也得到了广泛的关注。现对APL的发病机制及最新的临床治疗进展进行总结和讨论。 Pathogenesis of acute promyelocytic leukemia is one of the best understood disease among human hematological malignancies. Becasue of retinoic acid （RA） and arsenic trioxide which directly target the oncogenic promyelocytic leukemia-retinoic receptor A （PML-RARα） fusion protein, this disease became the first model for oneogene-targeted therapies.And other new therapy methods also gain great concern. The complexity of recent views of acute promyelocytic leukemia pathogenesis, as well as latest progress in clinical treatment were summarized and discussed in this review.
作者 谢琴芬(综述) 金洁(审校) 黄健(审校)
机构地区 浙江大学医学院附属第一医院血液科
出处 《白血病．淋巴瘤》 CAS 2009年第10期636-638,共3页 Journal of Leukemia & Lymphoma
关键词 白血病 PML—RAR α 维甲酸 治疗 Leukemia PML-RARα Tretinoin Therapy
分类号 R733.7 [医药卫生—肿瘤] R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献31

  • 1Rego EM, Pandolfi PP. Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models. Semin Hematol, 2001, 38: 54-70.
  • 2Park DJ, Vuong PT, de Vos S, et al. Comparative analysis of genes regulated by PMU RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays. Blood, 2003, 102:3727 -3736.
  • 3Rego EM, Wang ZG, Peruzzi D, et al. Role of promyelocytic leukemia (PML)protein in tumor suppression. J Exp Med, 2001, 193: 521-529.
  • 4Gurrieri C, Capodieci P, Bemardi R, et al. Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst, 2004, 96: 269-279.
  • 5Bernardi R, Pandolfi PP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene, 2003, 22: 9048-9057.
  • 6Lin HK, Bergmann S, Pandolfi PP. Cytoplasmic PML function in TGF-beta signaling. Nature, 2004, 431: 205-211.
  • 7van Wageningen S, Breems-de Ridder MC, Nigten J, et al. Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RAR alpha. Blood, 2008, 111: 1634-1643.
  • 8Du C, Redner RL, Cooke MP, et al. Overexpression of wild-type retinoic acid receptor alpha (RAR alpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelpcutic leukemia RAR alpha-fusion genes. Blood, 1999, 94: 793-802.
  • 9Meani N, Minardi S, Lieeiulli S, et al. Molecular signature of retinoic acid treatment in acute promyelocytic leukemia. Oncogene, 2005, 24: 3358- 3368.
  • 10Rego EM, Wang ZG, Peruzzi D, et al. Role of promyelocytic leukemia (PML) protein in tumor suppression. J Exp Med, 2001, 193: 521-529.

二级参考文献28

共引文献6

同被引文献56

  • 1欧阳仁荣,孙关林.全反式维甲酸诱导分化治疗急性早幼粒细胞白血病五年研究总结[J].中华肿瘤杂志,1993,15(2):125-129. 被引量：14
  • 2李新,赵耀中,李妍,李增军,袁晓莉,邹德慧,杨仁池,韩明哲,王建祥,邱录贵.高白细胞急性早幼粒细胞白血病49例临床分析[J].中华血液学杂志,2006,27(3):205-207. 被引量：5
  • 3张莉,李睿,李大鹏,刘永泽,徐世才,郝玉书,肖志坚.急性早幼粒细胞白血病治疗的远期疗效观察[J].中华血液学杂志,2007,28(1):15-18. 被引量：11
  • 4林愈灯,李永康,沈亦逵,王耀平.急性早幼粒细胞白血病治疗进展[J].中国小儿血液与肿瘤杂志,2007,12(1):37-40. 被引量：2
  • 5Lo Coco F, Diverio D, Falini B, et al. Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia. Blood, 1999, 94: 12-22.
  • 6Wang ZY, Chen Z. Acute promyelocytie leukemia: from highly fatal to highly curable. Blood, 2008, 111 : 2505-2515.
  • 7Fenanx P, Chomienne C, Degos L. All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia. Seminars Hematol, 2001,38:13.
  • 8Mathews V, George B, Lakshmi KM, et al. Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood, 2006, 107: 2627-2632.
  • 9Shen ZX, Shi ZZ, Fang J, et al. All-trans retinoie acid/As203 combination yields a high quality remission and survival in newly diagnosed acute promyeloeytie leukemia. Proc Natl Acad Sci U S A, 2004, 101: 5328-5335.
  • 10Sanz MA, Lo Coco F, Martin G, et al Definition of relapse risk and role ofnonanthracycline drugs fou consolidation in Patients with acute promyelocytic leukemia:a joint study of the PETHEMA and GMEMA cooperative groups. Blood, 2000, 96: 1247-1253.

引证文献6

二级引证文献33

白血病．淋巴瘤
2009年 第10期

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