摘要
以氨水为胺化剂,KMnO4为氧化剂,在不同反应条件下实现2-甲氧基-5-硝基吡啶6位的氧化胺化反应,探讨了溶剂类型、氨水浓度等反应条件对目标化合物产率影响。结果表明,以KMnO4,NH3/DMSO,H2O为氧化胺化体系,在30℃条件下持续通入氨气,反应时间4h,2-氨基-6-甲氧基-3-硝基吡啶收率最高达到92.5%。
2-methoxy-5-nitropyridine was reacted with aqueous ammonia and KMnO4 under several different conditions. Substitutions in the 6 position to the nitro group were obtained. The type of solvents, concentration of the aqueous ammonia etc on the yields of target compounds were investigated. The result showed that the yields of target compounds can be reached to 92.5 % with reacting temperature.at 30℃, reacting time by 4 h under the oxidative amination system of KMnO4, NH3/DMSO, H2O when ammonia gas was passed through.
出处
《广东化工》
CAS
2009年第10期59-60,共2页
Guangdong Chemical Industry
