摘要
目的探讨急性脑出血后血清S-100B蛋白的含量变化、临床意义。方法选取小型猪16只,随机分为实验组(脑出血模型组)10只和对照组(假手术组)6只。ELISA法测定术后血清6h、1 d、2d、3 d、5 d、7dS-100B浓度;结果血清S-100B浓度在6h即开始升高,在3d达高峰,其后开始下降,实验组6h到7d血清、S-100B浓度与对照组比较有显著差异(P<0.01)。实验组内第3d与第1 d的浓度比较有显著性差异(P<0.01)。结论血清S-100B浓度检测能反映脑组织的损害情况,为判断病情及预后提供依据,为全脑保护治疗及血肿清除术包括微创血肿清除术提供了理论支持。
Objective To explore the content change and clinical meaning of serum S -100B in acute cerebral hemorrhage of pig. Methods 16 pigs were randomly divided into 2 groups, the experiment （ hemorrhage model） group（n = 10） and control （sham operation） group（, =6）. The level of Serum S -100B was measured on days 1/4,1,2,3,.5,7 by enzyme linked immunosorbent assays （ ELISA ）. Results The level of S100B became to increase at 6h,te the top at 3d, then decrease. There was significant difference of serum NSE and S - 100B at 6h and 7d be- tween control group and experiment group （P 〈0.01 ）. And in the experiment group, there was significant difference between the first and third day （P 〈0. 01 ）. Conclusion Detecting content of S -100B dynamically might serve as a clinical index of predicting the short term neurological outcome and evaluating the degrees of neurological deficiency reliably. We should also think highly of the protection treatment of glial cell besides neuron protection treatment in cerebral hemorrhage.
出处
《湖北民族学院学报（医学版）》
2009年第3期1-3,共3页
Journal of Hubei Minzu University(Medical Edition)
基金
国家自然科学基金项目(30570628 30770751)
