摘要
目的:制备冬凌草甲素亚微乳,并对其理化性质进行表征。方法:采用高压均质法制备冬凌草甲素亚微乳,并对其粒径、Zeta电位、黏度等性质进行表征。结果:冬凌草甲素亚微乳为白色不透明乳状液体,载药量1g·L-1,平均粒径(138.87±0.60)nm,Zeta电位(47.27±2.31)mV,pH(6.02±0.03),黏度(1.78±0.015)MPa.s。结论:本实验所制得的冬凌草甲素亚微乳理化性质较稳定,工艺简单,可为冬凌草甲素亚微乳制剂的制备提供研究依据。
Objective：To prepare the oridonin submicron emulsion and characterize their properties. Method：High pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size,Zeta potential and viscosity were characterized. Result：The results showed that the submicron emulsions was formed with the drug loading 1 g·L^-1,particle size of （138.87±0.60） nm,zeta potential of （47.27±2.31） mV,pH value of （6.02±0.03） and viscosity of （1.78±0.015） MPa·s,respectively. Conclusion：The method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第20期2590-2593,共4页
China Journal of Chinese Materia Medica
关键词
冬凌草甲素
亚微乳剂
理化性质
oridonin submicron emulsion physicochemical properties
