摘要
目的:对2型糖尿病患者的肾小球滤过率(GFR)、内生肌酐清除率(Ccr)、糖化血红蛋白(HbA1c)、尿微量白蛋白(mA1b)等指标进行分析,探讨肾小球滤过率和内生肌酐清除率对糖尿病肾病的临床指导意义。方法:对72例2型糖尿病住院患者测量收缩压(SBP)、肾小球滤过率、内生肌酐清除率、糖化血红蛋白、尿微量白蛋白等指标。采用t检验、方差分析和线性回归分析评价2型糖尿病患者GFR、Ccr、DM病程等指标的相关情况。结果:GFR与糖尿病病程呈负相关(r=-0.416,回归系数为-0.416,P<0.0001),GFR与Ccr呈正相关(r=0.578,回归系数为0.464,P<0.001),Ccr与糖尿病病程呈负相关(r=-0.174,回归系数为-0.174,P<0.001)。结论:2型糖尿病患者GFR变化与糖尿病病程的相关性大于Ccr与糖尿病病程的相关性,且GFR与SBP、mA1b、Ccr等指标都密切相关。
Objective： To observe changes of glomerular filtration rate （GFR）, glyeosylated hemoglobin （HbAlc）, urinary microalbumin （mAlb）, triglyceride （TG） in patients with type 2 diabetes mellitus. The aim of this study was to discuss the relationships between them and to compare the clinical guiding significance of GFR and Ccr. Methods： From 2007 to 2008, 72 diabetic patients were assayed systolic blood pressure （SBP）, renal glomerulus filtering coefficient （GFR）, endogenous creatinine clearance rate （Ccr）, glycosylated hemoglobin（HbAlc）, urinary microalbumin （mAlb） and so on. We analyzed the association among GFR, Ccr, the course of disease and other indicators by T-test, ANOVA or linear regression. Re- sult： The correlation analysis indicated that the course of diabetes was negatively correlatied with the course of disease （r =--0. 416, coefficient b=--0. 416, P〈0. 0001）. Ccr was positively correlatied with GFR （r =0. 578, b=0.464, P〈0.001）. Ccr was negatively correlatied with GFR （r =--0.174,coeffi- cient b=--0. 174, P〈0. 001）. Conclusion： The dependability between GFR and diabetic duration was higher than that between GFR and Ccr, and GFR, SBP, mAlb, Ccr. And other indicators had a close cor relation.
出处
《新疆医科大学学报》
CAS
2009年第10期1453-1455,共3页
Journal of Xinjiang Medical University
