摘要
【目的】探讨8号染色体异常在急性白血病中的检出率及预后。【方法】采用G显带常规技术对332例急性白血病患者的染色体核型进行分析。【结果】8号染色体异常患者31例，检出率为9．3％；t（8；21）18例，检出率为5．4％，其中15例完全缓解（CR）（83．3％），与本科同期急性髓系白血病（AML）（不包括M3）相比差异有统计学意义（X^2=4．981，P=0．026）；8号三体8例，检出率为2．4％，其中5例CR（62．5％），与本科同期AML（不包括M3）相比差异无统计学意义（X^2=0．005，P=0．942），其余少见类型如t（8；13）、t（8；14）、t（8；20）、t（8；22）、8p^-，仅t（8；22）CR。【结论】t（8；21）是8号染色体异常中最常见的核型改变，预后良好；其次为8号三体，在AML中预后中等，而在急性淋巴细胞白血病（ALL）中预后差；其余少见异常多见于ALL且预后均差。
[Objective]To explore the incidence and prognosis of abnormality of chromosome 8 in acute leukemia. [Methods] Conventional cytogenetie technique of G-hand was used to analyze the karyotypes in 332 acute leukemia patients. [Results] Thirty one cases with abnormalities of chromosome 8 were found and the detection rate was 9.3%. Among them, 18 patients had t（8;21）, 8 had ＋8, and 5 had other abnormalities such as t（8;13）, t（8;14）, t（8;20）, t（8;22） and 8p . The complete remission （CR） rate of t（8;21） was higher than that of all cases of acute leukemia, and there were statistical significances between them（X^2 =4. 981, P =0. 026 ）. There were no differences in the CR rate between all cases of acute leukemia and＋8 （X^2 =0. 005, P =0. 942 ）. In other 5 patients onlY t（8;22） acquired CR. [Conclusion] t（8;21） is the frequent abnormality in chromosome 8, which has favorable prognosis, and ＋8 has intermediate prognosis in acute monocytie leukemia（AML） and adverse.prognosis in acute lymphocytic leukemia （ALL）. The most other abnormalities （4/5） are found in ALL and all have adverse prognosis.
出处
《医学临床研究》
CAS
2009年第10期1834-1837,共4页
Journal of Clinical Research
关键词
白血病
急性病
染色体异常
leukemia
acute disease
chromosome abnormalities
