摘要
综述一氧化氮供体抗肿瘤作用机制的实验研究新进展,分类介绍一氧化氮供体型化合物及其抗肿瘤活性。一氧化氮供体可通过靶向释放一氧化氮,直接杀伤肿瘤细胞,提高肿瘤细胞对放化疗的敏感性,增强免疫系统作用,削弱肿瘤细胞侵袭能力,并抑制其转移,从而发挥抗肿瘤作用。
The recent experimental researches on the anti-tumor mechanism of nitric oxide （NO） donors were reviewed. NO donor compounds and their anti-tumor activities were introduced classifiedly.By targeting release of NO, NO donors kill directly tumor ceils, strengthen the effect of immune system, to display anti-tumor activities. tumor ceils, enhance radioand ehemo-sensitivity of as well as inhibit tumor invasion and metastasis so as
出处
《药学进展》
CAS
2009年第10期438-445,共8页
Progress in Pharmaceutical Sciences
关键词
一氧化氮供体
抗肿瘤活性
作用机制
实验研究
NO donor
anti-tumor activity
mechanism of action
experimental research
