摘要
目的:研究中药安慰剂对胃肠动力和镇痛抗炎是否有药效学作用。方法:采用小鼠小肠推进和新斯的明亢进实验来观察中药安慰剂是否对胃肠动力有影响;采用小鼠热板镇痛法和二甲苯致小鼠耳肿胀实验来观察中药安慰剂是否有镇痛抗炎作用。结果:安慰剂、含5%原药加辅料组、含10%原药加辅料组与正常组比较均无统计学意义(P>0.05),阳性对照药与正常组比较有显著的统计学意义。结论:安慰剂、含5%原药加辅料、含10%原药加辅料对胃肠动力没有影响,并没有镇痛抗炎作用,提示本课题含有临床中药试验药低浓度(5%和10%)经以上实验结果表明没有药效学作用,从而起到了作为中药安慰剂对照的作用,为临床中药安慰剂的制作提供了实验依据,亦为本课题(中德合作中医药治疗腹泻型肠易激综合征的临床研究)中所采用含有5%试验药成分作为临床中药安慰剂对照提供实验依据。
Objective Study on the pharmacodynamics effects of traditional Chinese medicine placebo on gastrointestinal motility and anti-inflammatory analgesic. Methods Using small intestine propulsive function and its hyperfunction experiment induced by neostigmine in mice to observe the effects of traditional Chinese medicine on gastrointestinal motility;hot-plate analgesia in mice and xylene-induced swelling experiments in mice to observe the effects of placebo on anti-inflammatory and analgesia. Results In above four experiments,there was statistical significance between positive control and normal group, while the placebo group, containing 5% of the original drug plus auxiliary group, containing 10% of the original drug plus auxiliary group and normal group had not statistically significance （P〉0.05）. Conclusion The placebo group, containing 5% of the original drug plus auxiliary group,containing 10% of the original drug plus anxiliary group showed no effect on gastrointestinal motility and analgesic anti-inflammatory experiments, thus there was no pharmacodynamic effect. The results demonstrated clinical medicine in this research project containing low concentration （5% and 10%） trial drug, had no pharmacodynamic effect on the above four experiments, which have played a role in placebo-controlled of the traditional Chinese medicine, and provided an experimental basis for the clinical placebo selection of Chinese medicine, also provided experimental basis for the project （Sino-German cooperation in TCM treatment of diarrhea-predominant irritable bowel syndrome） using in 5% of the placebo-controlled clinical medicine.
出处
《深圳中西医结合杂志》
2009年第5期273-278,共6页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
国家科技部国际合作项目(2007DFA30560)
关键词
中药安慰剂
小肠推进
新斯的明
抗炎
镇痛
Medicine placebo
Intestinal propulsion
Neostigmine
Analgsia
Anti-lnflammatory
