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PTEN在纤维化疾病中的作用 被引量：1

Functions of PTEN in the pathogenesis of fibrosis diseases
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摘要 第10号染色体同源丢失性磷酸酶-张力蛋白基因(PTEN)作为肿瘤抑制基因,可以负性调节肿瘤细胞的生长。目前发现PTEN在纤维化疾病中也有重要的作用和意义,但其与肝纤维化的关系尚不明确,对PTEN在各器官纤维化中的作用这一问题的深入研究可能为纤维化疾病的治疗提供新的思路。本文就近年来PTEN在纤维化疾病中的作用和意义作一综述。 As a tumor-suppressor gene, phosphatase and tensin homology deleted on chromosome 10（PTEN） regulates negatively the growth of tumor cells. PTEN is also found to play an important role in fibrosis diseases, while the relationship between PTEN and hepatic fibrosis is still unknown. Extensive and intexrsive research about the role of PTEN in fibrosis diseases may provide new insight into the treatment for fibrosis diseases.
作者 何晓童 樊晓明
机构地区 复旦大学附属金山医院消化内科
出处 《国际内科学杂志》 CAS 2009年第10期584-586,590,共4页 International Journal of Internal Medicine
关键词 PTEN 纤维化 信号转导 PTEN Fibrosis Signal transduction
分类号 R349.54 [医药卫生—基础医学]
  • 相关文献

参考文献23

  • 1Gimm O, Attie-Bitach T, Lees JA, et al. Expression of the PTEN tumor suppressor protein during human development. Hum Mol Genet, 2000, 9( 11 ) :1633-1639.
  • 2Sulis ML, Parsons R. PTEN: from pathology to biology. Trends Cell Biol, 2003, 13(9) :478-483.
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  • 5程悦,李芙蓉,袁发焕.PTEN编码蛋白对TGF-β_1刺激大鼠肾成纤维细胞增殖的抑制作用[J].解放军医学杂志,2006,31(5):407-409. 被引量：6
  • 6Runyan CE, Schnaper HW, Poncelet AC. The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimula- ted mesangial cell collagen I expression in response to transforming growth factor-betal. J Biol Chem, 2004, 279 (4) : 2632-2639.
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二级参考文献15

  • 1王代红,袁发焕,邓剑波.肥大细胞类胰蛋白酶对人肾成纤维细胞增殖和I型胶原表达的影响[J].重庆医学,2005,34(4):533-535. 被引量：6
  • 2程悦,李芙蓉,袁发焕.PTEN对大鼠肾成纤维细胞增殖能力的影响[J].重庆医学,2006,35(4):341-343. 被引量：4
  • 3Rodemann HP,Muller GA,Knecht A et al.Fibriblasts of rabbit kidney in culture.Ⅰ.Characterization and identification of cell-specific markers.Am J Physiol,1991,261:283.
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  • 5Gimm O,Attie BT,Lees JA et al.Expression of the PTEN tumour suppressor protein during human development.Hum Mol Genet,2000,9:1633.
  • 6Sulis ML,Parsons R.PTEN:from pathology to biology.Trent Cell Biol,2003,13:478.
  • 7Eric SW,Victor JT,Shannon LC et al.Integrin α4β1 regulates migration across basement membranes by lung fibroblasts.Am J Respir Crit Care Med,2003,168:436.
  • 8Oudit GY,Sun H,Kerfant BG et al.The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease.J Mol Cell Cardiol,2004,37(2):449.
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共引文献6

同被引文献4

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二级引证文献6

国际内科学杂志
2009年 第10期

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