摘要
目的:探讨胆管引流联合CT导引下125I粒子植入治疗恶性梗阻性黄疸的安全性、疗效。方法:19例MOJ患者先行介入性减黄术,术后4~6周在CT导引下接受125I粒子植入术。术后2月评估肿瘤近期疗效,统计累计生存率。结果:行胆管内支架植入术3例,单纯性胆管外引流4例,内外引流术12例。单个瘤体内植入粒子数为8~60粒,平均27.1粒。粒子植入术中和术后未见明显并发症发生。肿瘤完全缓解1例,部分缓解8例,有效率47.4%(9/19)。6,12,18,24,30,36月生存率分别为57.9%(11/19),36.8%(7/19),26.3%(5/19),15.8%(3/19),15.8%(3/19),0%(0/19)。结论:胆管引流联合CT引导下125I粒子植入治疗恶性梗阻性黄疸安全,且具有较好的疗效。
Objective： To explore the safety and efficacy of interventional cholangiography drainage combined with CT guided percutaneous 125^Ⅰ seeds implantation treatment for malignant obstructive jaundice （MOJ）. Methods： Nineteen patients with MOJ were carried out alleviative jaundice by interventiona! technique,and performed CT guided percutaneous 125^Ⅰ seeds implantation after 4-6 weeks. The clinical efficacy and accumulative survival rate were evaluated after the procedures. Results： Three patients with MOJ were carried out an expandable metallic-biliary endoprothesis （EMBE）, and the sixteen percutaneous transhepatic cholangiography drainage （PTCD）. Eight to sixty （mean 27.1） 125^Ⅰ seeds were implanted into a single tumor at first time. No obvious complication occurred during the procedure. The total clinical efficacy was 47.4 % （9/19）with CR 1, and PR 8. The survival rates of 6,12,18,24,30,36 months were 57.9%（11/19）,36.8%（7/19）,26.3%（5/19）,15.8%（3/19） ,15.8% （3/19） and 0 % （0/19） respectively. Conclusion ： Interventional eholangiography drainage combined CT guided percutaneous 125^Ⅰ seeds implantation treatment for malignant obstructive jaundice is not only safe, but also definitely effective.
出处
《中国中西医结合影像学杂志》
2009年第5期335-337,341,共4页
Chinese Imaging Journal of Integrated Traditional and Western Medicine
基金
浙江医学高等专科学校自然科学研究资助项目(编号:2005XZ011)
关键词
梗阻性黄疸
恶性
经皮肝穿刺胆管引流术
生存率分析
125^Ⅰ粒子
Obstructive jaundice, malignant
Percutaneous transhepatic cholangiography drainage
Analysis of survival rate
125^Ⅰ seeds
