摘要
目的探讨黏附分子在阻塞型睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)与冠状动脉粥样硬化性心脏病(冠心病)关系中的作用。方法应用酶联免疫吸附法(ELISA)检测31例OSAHS合并冠心病患者(OSAHS+CHD组)、31例单纯OSAHS患者(OSAHS组)和28例健康志愿者(正常对照组)血清中细胞间黏附分子1(ICAM-1)、血管细胞黏附分子1(VCAM-1)的含量。结果OSAHS+CHD组和OSAHS组血清中ICAM-1高于正常对照组(P<0.05);OSAHS组血清VCAM-1与正常对照组比较差异有统计学意义(P<0.05),而OSAHS+CHD组血清VCAM-1与正常对照组比较差异无统计学意义。OSAHS患者的ICAM-1与睡眠呼吸暂停低通气指数呈显著正相关(r=0.544,P<0.01),ICAM-1、VCAM-1均与体质量指数呈正相关(r=0.280,P<0.05)。结论血清ICAM-1水平增高是OSAHS患者发生冠心病的重要危险因子之一。
Objective To explore the role of adhesion molecules in the relationship between obstructive sleep apnea-hypopnea syndrome（OSAHS） and coronary heart disease（CHD）.Methods The levels of serum soluble intercellular adhesion molecule-1（ICAM-1） and vascular cell adhesion molecule-1（VCAM-1） in 31 OSAHS patients with CHD,31 OSAHS patients without CHD and 28 healthy controls were measured by enzymed-linked immunosorbent assay（ELISA）.The relationship of the concentration of ICAM-1,VCAM-1 with the polysomnogram parameters was analyzed.Results The levels of serum ICAM-1 in OSAHS patients with CHD and OSAHS patients without CHD were significantly higher compared with the healthy controls（P〈0.05）.The level of serum VCAM-1 in OSAHS patients was significantly higher than that in the healthy controls（P〈0.05）,but the level of serum VCAM-1 did not significantly differ between OSAHS patients with CHD and the healthy controls（P〉0.05）.ICAM-1 in OSAHS patients positively correlated with apnea-hypopnea index（AHI）（r=0.544,P〈0.01）.ICAM-1 and VCAM-1 also showed significantly positive correlation with body mass index（BMI）（r=0.280,P〈0.05）.Conclusion The high levels of serum ICAM-1 is an important risk factor for the development of CHD in OSAHS patients.
出处
《首都医科大学学报》
CAS
北大核心
2009年第5期687-690,共4页
Journal of Capital Medical University
基金
国家自然科学基金(C03030201)资助项目~~
