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差异表达基因谱预测下咽鳞癌化疗敏感性的临床研究

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摘要 目的探讨差异表达基因谱预测下咽鳞癌化疗敏感性的临床应用。方法回顾性分析41例接受诱导化疗的下咽鳞癌临床病理资料,自不同化疗敏感性的下咽鳞癌差异基因表达谱中,随机选取CDDN1、FAS、STAT基因作为差异基因表达谱标志,检测各基因表达,Logistic回归模型分析差异表达基因谱和单一基因预测化疗敏感性的准确性。结果在41例下咽鳞癌中,化疗敏感19例,其中CDDN1、FAS、STAT3和差异基因表达谱阳性表达率分别为57.9%(11/19)、57.9%(11/19)、47.4%(9/19)和78.9%(15/19),均高于化疗不敏感组,差异有统计学意义(P<0.05)。CDDN1、FAS、STAT3和差异基因表达谱阳性表达与化疗敏感符合率分别为57.9%(11/19)、63.2%(12/19)、47.3%(9/19)和78.9%(15/19)。FAS和差异基因表达谱预测下咽鳞癌化疗敏感性的准确率分别为68.3%(P<0.05)和85.4%(P<0.001)。结论差异基因表达谱可较准确地预测下咽鳞癌化疗敏感性,准确率高于单一基因。
作者 邢海杰 曾宗渊 郭朱明 杨安奎 李浩
机构地区 中山大学肿瘤防治中心头颈科
出处 《苏州大学学报（医学版）》 CAS 北大核心 2009年第4期798-799,801,F0003,共4页 Suzhou University Journal of Medical Science
关键词 下咽 鳞癌 化疗 敏感性 预测
分类号 R739.65 [医药卫生—肿瘤]
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参考文献7

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二级参考文献31

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苏州大学学报（医学版）
2009年 第4期

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