摘要
利用三组分氮杂Wittig反应,以三氢环戊二烯并噻吩基三苯基膦亚胺、对氟苯基异氰酸酯和酚,合成了13个未见文献报道的2-芳氧基-3-对氟苯基-3,5,6,7-四氢-4H-环戊二烯并[4,5]噻吩并[2,3-d]-嘧啶-4-酮衍生物,产率58%～73%.通过IR,1HNMR,MS和元素分析对目标化合物的结构进行了表征.初步探讨了所合成化合物的抑菌活性,结果显示所合成的化合物对真菌(桔青霉菌)的抑制活性优于对细菌的抑制活性.
Thirteen new 2-aryloxy-3-（4-fluoropheny1）-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]-pyrimidin-4-ones were synthesized in 58%-73% yields by aza-Wittig reaction of （4,5,6-trihydrocyclopentathiophen-2-ylimino）（triphenyl）phosphorane with 4-fluorophenyl iso-cyanate, and subsequent reaction with phenols. Their structures were confirmed by IR, ^1H NMR, MS techniques and elemental analyses. Their bacteriostatic activities were tested and the results showed that their bacteriostatic activities against fungus （Penicillium citrinum Thorn） were better than those against bacteria.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第10期1582-1586,共5页
Chinese Journal of Organic Chemistry
基金
天然产物研究与应用湖北省重点实验室开放研究基金(No.2006NP01)
三峡大学自然科学基金(No.HY0803)
湖北省教育厅自然科学研究(No.D20091301)资助项目
