摘要
目的：探讨血脂分析与CTnI和ET测定在慢性肾脏疾病诊断中的临床应用,。方法：在肾脏疾病患者未使用抗脂药物时,生化法测定了204例慢性肾脏疾病患者,其中63例尿毒症,65例肾病综合征（NS）,76例慢性肾小球肾炎（CGN）和60例正常对照组血浆中的血脂水平,化学发光免疫分析和RIA测定了血浆CTnI和ET水平。结果：在血脂分析中,63例尿毒症,65例NS和76例CGN,血浆apoA、apoB和LP（a）水平较之60例正常对照组均明显增高（P〈0.05-〈0.01）。而尿毒症中的血浆TC和LDL-C水平,NS中的血浆TG水平和CGN中TC、TG和LDL-C水平较之正常对照组无明显差异（P〉0.05）,其他指标甚至降低,有人称之为＂逆流行病学＂现象。尿毒症、NS和CGN血浆CTnI和ET水平均增高。结论：慢性肾脏疾病中,血脂分析中apoA、apoB和LP（a）是诊断的良好指标。血浆CTnI和ET的测定对慢性肾脏疾病的诊断和随访治疗更有帮助。
Objective To study the diagnostic application of determination of changes of plasma lipids,CTnI and ET contents in patients with chronic renal diseases.Methods Plasma lipids（with biochemistry）,CTnI（with CLIA） and ET（with RIA） contents were measured in 63 patients with uremia,65 patients with nephrosis and 76 patients with chronic glomerular nephritis as well as 60 controls.Results The plasma apoA,apoB and LP（a） levels in the patients with chronic renal diseases as a whole were significantly higher than those in controls（P〈0.05P〈0.01）.With respect to the three different types of chronic renal diseases,the plasma TC ad LDL-C levels in patients with uremia,the plasma TG levels in patients with nephrosis and plasma TC,TG and LDL-C levels in patients with chronic glomerular nephritis were not significantly different from those in controls（P〉0.05）.The plasma cTnI and ET levels in all there three types of patients with chronic renal disease were significantly higher than those in controls.Conclusion In patients with chronic renal disease,the plasma apoA,apoB,LP（a）,cTnI and ET levels were consistently significantly increased and might be of diagnostic and prognostic importance.
出处
《放射免疫学杂志》
CAS
2009年第5期457-459,共3页
Journal of Radioimmanology
