摘要
为降低嗜水气单胞菌耐药菌株的产生速度,延长恩诺沙星在水产动物上的应用年限,通过建立体外模型的方法,研究恩诺沙星对嗜水气单胞菌的药动-药效(PK-PD)参数。在消除半衰期为100h的模型内,2MIC(最小抑菌浓度)的恩诺沙星对嗜水气单胞菌能够抑制6h,6h后细菌出现再生长;4、8和16MIC对嗜水气单胞菌能够起到持续的抑制作用。在消除半衰期为168h的模型内,2MIC的恩诺沙星对嗜水气单胞菌能够抑制6h,6h后细菌出现再生长;4、8和16MIC对嗜水气单胞菌能够起到持续的抑制作用。结果表明,当AUC0→24/MIC>75.24±13.24,Cmax/MIC>4.10±0.12时,恩诺沙星对嗜水气单胞菌能够起到持续的抑制作用。
The purposes of this research is to decrease the occurrence speed of resistant Aeromonas hydrophila and prolong the time limit of enrofloxacin application on aquatic creature. By using in vitra pharmacokinetic model, PK-PD parameter of Aerornonas hydrophila against enrofloxacin was studied. In the in vitro model with elimination half-life of 100 h, Aeromonas hydrophila was inhibited for 6 h by 2 MIC enrofloxacin and was continuously inhibited in the entire experiment period of 24 h by 4, 8 and 16 MIC enrofloxacin. In the in vitro model with elimination half-life of 168 h, the inhibitation effect of 2 MIC enrofloxacin on Aeromonas hydrophila lasted for 6 h and the bacteria regrew after that. 4, 8 and 16 MIC enrofloxacin showed continously inhabitative action on Aeromonas hydrophila. It concluded that continous inhabitation of Aeromonas hydrophila by enrofloxacin could be achieved at the condition of AUC0→24/ MIC〉75.24±13.24, Cmax/MIC〉4.10±0.12.
出处
《东北农业大学学报》
CAS
CSCD
北大核心
2009年第10期91-96,共6页
Journal of Northeast Agricultural University
基金
农业部水生动物遗传育种和养殖生物学重点实验开放实验室基金(BM2007-12)
"十一五"国家科技支撑计划(2006BAD03B04)
农业公益性行业专项(200803013)
关键词
体外药动模型
恩诺沙星
嗜水气单胞菌
in vitro pharmacokinetic model
enrofloxacin
Aeromonas hydrophila
