摘要
目的：研究声门上型喉癌组织中ｎｍ２３／ＮＤＰＫ的表达及与癌恶性度和颈淋巴结转移之间的关系。方法：应用免疫组化Ｓ－Ｐ法。结果：８０例喉癌原发灶中ＮＤＰＫ表达阳性率５８．８％；其中无颈淋巴结转移者阳性率为６９．８％，伴有颈淋巴结转移者阳性率４５．８％，差异有显著性意义（Ｐ＜０．０５）。低度恶性原发灶中ＮＤＰＫ表达阳性率６８．８％，高度恶性阳性率４５．９％，差异有显著性意义（Ｐ＜０．０５）。高度恶性原发灶ＮＤＰＫ表达阴性病例颈淋巴结转移率显著高于低度恶性ＮＤＰＫ表达阳性病例颈淋巴结转移率（Ｐ＜０．０１）。结论：ｎｍ２３基因在声门上型喉癌颈淋巴结转移过程中发挥负性调控作用。
Objective:This paper was to study the relationship between the expression of nm23/NDPK in supraglottic laryngeal carcinoma tissue and the degree of malignancy as well as cervical lymph node metastasis. Methods:Eighty cases of this carcinoma in 1990 and 1991 were randomly selected from our hospitel. We used immunohistochemical S P method.Results:The positive staining rate of NDPK in primary laryngeal carcinoma was 58.8%. The positive staining rate was 69.8% in patients without cervical lymph node metastasis, and 45.8% in those with cervical lymph node metastasis. The positive expression rate was 68.8% in primary lesions with lowdegree malignance,and 45.9% in those with high degree malignancy. The cervical lymph node metastasis rate was significantly higher(P<0.01) in high degree malignant primary lesions with negative NDPK expression than that in low degree malignant primary lesions with positive NDPK expression. Conclusions:nm23 gene playd a role of inverse control in cervical lymph node metastasis for supraglottic laryngeal carcinoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1998年第5期521-524,共4页
Journal of China Medical University
