摘要
[目的]建立黄芩苷缓释片释放度的紫外测定方法,并考察其体外释放机制。[方法]采用紫外分光光度法测定黄芩苷缓释片的体外释放度,并对影响释药的因素进行了单因素考察。[结果]羟丙甲纤维素(HPMC)的规格和用量对释药速率有显著影响,黄芩苷缓释片的体外释放曲线基本符合Higuchi方程。[结论]该研究方法简便、快速,体外释放度显示黄芩苷缓释片处方设计比较合理,可进一步研发。
[Objective] To establish a UV method to determine the dissolution of baicalin extended-release tablets and determine its release mechanism in vitro. [Methods] The extracorporal dissolution of baicalin extended-release tablets was determined by UV method, the factors that influence drug release were determined by single factor investigation. [Results] Both qualification and dosage of HPMC had significant influence on the rate of drug release. The release curve in vitro of baicalin extended-release tablets fitted Higuchi equation fundamentally. [Conclusion] The UV method is simple and quick, the extracorporal dissolution show that the prescription of the extended-release tablets is reasonable relatively, it was worthy for further research.
出处
《天津中医药》
CAS
2009年第5期426-428,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
国际科技合作计划项目(2007DFC31670)
国家科技支撑计划项目(2007BAI47B01)
关键词
黄芩苷
缓释片
释放度
baicalin
extended-release tablets
dissolution
