摘要
综述了硅烷化试剂的特点、保护原理和应用,重点介绍了硅烷化试剂在药物合成中的应用,举例介绍了氨苄西林、前列腺素、辛伐他汀和[(+)-Detoxinine]等药物中羟基的保护和去保护条件。
The characteristics,protection principle and application of silylation reagents were reviewed.The application of silylation reagents to drug synthesis was mainly introduced.For example,the protection and de-protection conditions for hydroxy of the drugs such as Ampicillin,Prostaglandin,Simvastatin,and [（＋）-Detoxinine].
出处
《化学与生物工程》
CAS
2009年第10期87-89,共3页
Chemistry & Bioengineering
基金
科技创新人才研究专项基金资助项目(2007RFJYG006)
关键词
位阻型
保护剂
硅烷化
药物合成
叔丁基二苯基氯硅烷
sterically hindered
protective agent
silylation
drug synthesis
tert-butyldiphenyl chlorosilane
