摘要
目的观察和比较伊布利特和胺碘酮转复心房颤动（房颤）射频消融术后早期复发房性心动过速（房速）的疗效和安全性。方法连续46例接受房颤射频消融后复发房速的患者，男性32例，女性14例，平均年龄（56±12）岁，分别静脉应用伊布利特（ibutilide，1．0mg／次，1～2次，10min内静脉推注）和胺碘酮（150me,／次，1～2次，10min内静脉推注）。观察转复率和转复时间，记录不良反应。结果4h内伊布利特组和胺碘酮组转复率分别为86．4％和41．7％（P=0．0023）；24h时内转复率分别为90．9％和62．5％（P=0．0376）。伊布利特组对持续时间〈24h的房速转复率为100％，胺碘酮组转复率为66．7％（P=0．0421）。伊布利特组平均转复时间为（13±8）min，胺碘酮组转复时间为（364-25）min（P〈0．01）。两组均未发生致命性不良反应，不良反应发生率差异无统计学意义。结论伊布利特和胺碘酮均能终止射频消融术后复发房速，伊布利特更快速、安全、有效。
Objective To evaluate the immediate efficacy and safety of intravenous ibutilide and amio- darone for termination of recurrent atrial tachycardia after catheter ablation of atrial fibrillation. Methods Forty-six consecutive patients with recurrent atrial tachycardia less than 90 days who underwent catheter ablation of atrial fibrillation were enrolled in this study [ 32 male, 14 female, aged（56 ± 12）yearsJ. The patients were ran- domly assigned to receive infusion of ibutilide （ ibutilide group, 1 to 2 times, 1.0 mg for each） or amiodarone （amiodarone group, 1 to 2 times, 150 mg for each）. Results Ibutilide was superior to amiodarone in treating recurrent atrial tachycardia after catheter ablation of atrial fibrillation （ 90. 9% vs 62.5%, P = 0. 0376 ）. The mean response time was （ 13 ± 8 ） rain in ibutilide group and （ 36 ±25 ） rain in amiodarane group （ P 〈 0. 01 ）. Conclusion Ibutilide can immediately terminate recurrent atrial tachycardia after catheter ablation of atrial fi- brillation safely and effectively.
出处
《中华心律失常学杂志》
2009年第5期340-343,共4页
Chinese Journal of Cardiac Arrhythmias
