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卵巢癌顺铂耐药机制的研究进展

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摘要 卵巢癌是严重威胁妇女健康的恶性肿瘤之一,近几年卵巢癌的发病率有增高的趋势,据报道,美国2007年有22430例卵巢癌新发病例。由于卵巢癌发病隐匿和缺乏完善的早期诊断方法,约70%患者确诊时已为晚期(FIGO分期,Ⅲ期和Ⅳ期),其死亡率居妇科恶性肿瘤的首位。在细胞减灭术的基础上施以以顺铂为主的联合化疗方案已成为卵巢癌的常规治疗方案。但由于卵巢癌患者对顺铂的原发性(primary drug resistance)和(或)获得性(acquired resistance)多药耐药(multiple drug resistance,MDR)的存在,
出处 《医学新知》 CAS 2009年第5期297-301,共5页 New Medicine
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