摘要
小白菊内酯是草本类植物艾菊的主要药物活性成分。大量的研究证实小白菊内酯具有多种药理作用,包括抗炎免疫抑制作用、抗氧化、抗肿瘤、抑制血管平滑肌细胞的增殖、抑制破骨细胞的活性及抑制细胞核因子-κB的表达等。文中就小白菊内酯抗炎、抗肿瘤等的最新研究做一综述,为该植物提取物的进一步研发提供参考。
Extracts from plants of sesquiterpene lactones have been used as folk remedies for migraine,inflammatory arthritis,and tumors.Parthenolide （PAR）,one of the major products from sesquiterpene lactones is an active ingredient responsible for many pharmacological activities including anti-inflammatory,antioxidand activities,anti-tumor activity,inhibiting the activation of NF-kappaB,ect.The review was to summarise some newly available research data about PAR and provide more information for further use of PAR.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第20期1954-1957,共4页
Chinese Journal of New Drugs
关键词
小白菊内酯
药理作用
生物特性
parthenolide
pharmacological activities
bioactivity
