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奥曲肽对溃疡性结肠炎大鼠肠组织NF-κB p65的影响 被引量：1

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摘要 目的探讨生长抑素(SST)类似物—奥曲肽对溃疡性结肠炎(UC)大鼠结肠组织核因子-κB(NF-κB)p65蛋白活性的影响及其机制。方法将雌性SD大鼠随机分为正常对照组、奥曲肽对照组、模型组、治疗组,每组各7只。模型组、治疗组大鼠用三硝基苯磺酸(TNBS)/乙醇溶液灌肠复制UC模型。评价各组实验大鼠大体及组织病理学改变,采用Western blot法检测结肠NF-κB p65蛋白的表达。结果奥曲肽可以显著改善结肠组织大体和组织学评分,降低NF-κB p65表达。结论NF-κB与UC发病关系密切,奥曲肽可能通过影响炎症反应的信号通路达到治疗目的。
作者 朱炳喜 刘元山 陈剑群
机构地区 徐州医学院附属医院
出处 《山东医药》 CAS 北大核心 2009年第40期30-31,共2页 Shandong Medical Journal
基金 江苏省徐州市科学技术局基金资助项目(XM07C065)
关键词 结肠炎 溃疡性 生长抑素 NF-ΚB
分类号 R574.6 [医药卫生—消化系统]
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参考文献10

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共引文献26

同被引文献16

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山东医药
2009年 第40期

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